Browsing Faculty of Arts and Sciences by Title
Now showing items 2485-2504 of 24540
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Cdx4 Is Dispensable for Murine Adult Hematopoietic Stem Cells but Promotes MLL-AF9-Mediated Leukemogenesis
(Ferrata Storti Foundation (Haematologica), 2010)Background: Cdx4 is a homeobox gene essential for normal blood formation during embryonic development in the zebrafish, through activation of posterior Hox genes. However, its role in adult mammalian hematopoiesis has not ... -
Celebrating Soft Matter's 10th anniversary: Testing the foundations of classical entropy: colloid experiments
(Royal Society of Chemistry (RSC), 2015)By performing experiments on colloids, one can establish that certain definitions of the classical entropy fit the data, while others in the literature do not. -
A celebration of the mathematical work of Glenn Stevens
(Springer Nature, 2015) -
Celebrities’ impact on health-related knowledge, attitudes, behaviors, and status outcomes: protocol for a systematic review, meta-analysis, and meta-regression analysis
(BioMed Central, 2017)Background: Celebrities are highly influential people whose actions and decisions are watched and often emulated by wide audiences. Many celebrities have used their prominent social standing to offer medical advice or ... -
Cell Aging in Relation to Stress Arousal and Cardiovascular Disease Risk Factors
(Elsevier, 2006)We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by tower PBMC telomerase and shortened tetomeres. Psychological stress is a major risk factor for ... -
The Cell Cycle and Differentiation in Stem Cells
(2013-03-08)The relationship between cellular proliferation and differentiation is a major topic in cell biology. What we know comes from models of somatic cell differentiation, where it is widely viewed that cycling and differentiation ... -
Cell Division Cycle 6, a Mitotic Substrate of Polo-Like Kinase 1, Regulates Chromosomal Segregation Mediated by Cyclin-Dependent Kinase 1 and Separase
(Proceedings of the National Academy of Sciences, 2010)Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 ... -
Cell Encapsulation in Sub-mm Sized Gel Modules Using Replica Molding
(Public Library of Science, 2008)For many types of cells, behavior in two-dimensional (2D) culture differs from that in three-dimensional (3D) culture. Among biologists, 2D culture on treated plastic surfaces is currently the most popular method for cell ... -
Cell Fate Decisions in Early Embryonic Development
(2013-10-08)The basis of developmental biology lies in the idea of when and how cells decide to divide or to differentiate. Previous studies have established several signaling pathways that determine cell fate decisions, including ... -
Cell Fate Determination in the Innate Immune System
(2021-09-08)Phagocytes of the innate immune system adopt cell fates that serve distinct purposes during homeostasis or inflammation. The innate immune system performs threat assessments by integrating pattern recognition receptor (PRR) ... -
Cell Migration Driven by Cooperative Substrate Deformation Patterns
(American Physical Society, 2010) -
Cell motility: Turning failure into function
(Springer Nature, 2013)In their search for more favourable environments bacteria choose new directions to explore, usually at random. In a marine bacterium with a single polar flagellum it is now shown that this quest is enhanced by a buckling ... -
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ... -
Cell Size Regulation in Bacteria
(American Physical Society (APS), 2014)Various bacteria such as the canonical gram negative Escherichia coli or the well-studied gram positive Bacillus subtilis divide symmetrically after they approximately double their volume. Their size at division is not ... -
Cell States and Cell Fate: Statistical and Computational Models in (Epi)Genomics
(2015-01-14)This dissertation develops and applies several statistical and computational methods to the analysis of Next Generation Sequencing (NGS) data in order to gain a better understanding of our biology. In the rest of the chapter ... -
Cell states and neuronal vulnerabilities in neurodegenerative diseases
(2022-09-14)Neurodegenerative diseases are pathologically characterized by the induction of gliotic states and the loss of specific neurons in the human brain. A precise ascertainment of cellular states altered and those types of ... -
Cell states and therapeutic targets in pancreatic cancer
(2023-05-11)Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer wherein treatment resistance is common and survival is poor. Prior transcriptional profiling studies have revealed two major cell states in untreated human ... -
Cell Type of Origin Influences the Molecular and Functional Properties of Mouse Induced Pluripotent Stem Cells
(Nature Publishing Group, 2010)Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly ... -
Cell Type-Specific Manipulation with GFP-Dependent Cre Recombinase
(2016)Summary There are many transgenic GFP reporter lines that allow visualization of specific populations of cells. Using such lines for functional studies requires a method that transforms GFP into a molecule that enables ... -
Cell-Based Discovery Methods Furnish New Compounds Effective Against Gram-Negative Bacteria
(2016-07-20)Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to continuously develop new antibiotics to stay ahead in this biological arms race. It is particularly important and challenging ...