Browsing Faculty of Arts and Sciences by Title

Now showing items 2649-2668 of 24540

    • Characterization of impaired CD8+ T cell responses to Chlamydia trachomatis 

      Fankhauser, Sarah Carmela (2013-10-15)
      Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Irregular screening to identify infected individuals and a lack of sterilizing immunity to C. trachomatis has ...

    • Characterization of Individual Polynucleotide Molecules Using a Membrane Channel 

      Kasianowicz, John J.; Brandin, Eric; Branton, Daniel; Deamer, David W. (National Academy of Sciences of the United States of America, 1996)
      We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or ...

    • Characterization of Iron-Imido Species Relevant forN-Group Transfer Chemistry 

      Iovan, Diana Alexandra; Betley, Theodore A (American Chemical Society (ACS), 2016)
      A sterically accessible tert-butyl-substituted dipyrrinato di-iron(II) complex [(tBuL)FeCl]2 possessing two bridging chloride atoms was synthesized from the previously reported solvento adduct. Upon treatment with aryl ...

    • Characterization of lung tumor-propagating cells reveals a role for CD24 and Yap/Taz in lung cancer progression and metastasis 

      Lau, Allison Nicole (2014-06-06)
      Lung cancer is the leading cause of cancer deaths worldwide. A large part of this high mortality rate is due to the onset of metastatic disease prior to diagnosis. Advances in treatment for metastatic disease may be achieved ...

    • Characterization of Malaria Sexual Stage Development in the Human Host 

      Joice, Regina Carol (2013-09-26)
      Due to an increase in malaria control programs in the last decade, the world has witnessed dramatic reductions in the number of infections and deaths caused by the malaria parasite. With malaria eradication on the global ...

    • Characterization of Nucleic Acids by Nanopore Analysis 

      Deamer, David W.; Branton, Daniel (American Chemical Society, 2002)
      Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information ...

    • Characterization of nucleosome occupancy in mammalian cells 

      Cook, April D (2014-10-21)
      Chromatin is a complex of genomic DNA, RNA, and associated proteins. Many of the processes that occur on chromatin regulate the accessibility of the genetic material of a cell. The nucleosome is the basic subunit of ...

    • Characterization of Protein-Metabolite and Protein-Substrate Interactions of Disease Genes 

      McFedries, Amanda Kathryn (2014-06-06)
      Discovery of protein-metabolite and protein-substrate interactions that can specifically regulate genes involved in human biology is an important pursuit, as the study of such interactions can expand our understanding of ...

    • Characterization of the Antibacterial Activity of the Type VI Secretion System 

      Ho, Brian Thomas (2014-02-25)
      This dissertation summarizes advances made toward understanding of the composition, structure, mechanism, and regulation of the bacterial type VI secretion system (T6SS). The T6SS is a widely conserved bacterial nanomachine ...

    • Characterization of the Benchmark Binary Nltt 33370 

      Schlieder, Joshua E.; Bonnefoy, Mickaël; Herbst, T. M.; Lépine, Sébastien; Berger, Edo; Henning, Thomas; Skemer, Andrew; Chauvin, Gaël; Rice, Emily; Biller, Beth; Girard, Julien H. V.; Lagrange, Anne-Marie; Hinz, Philip; Defrère, Denis; Bergfors, Carolina; Brandner, Wolfgang; Lacour, Sylvestre; Skrutskie, Michael; Leisenring, Jarron (IOP Publishing, 2014)
      We report the confirmation of the binary nature of the nearby, very low-mass system NLTT 33370 with adaptive optics imaging and present resolved near-infrared photometry and integrated light optical and near-infrared ...

    • Characterization of the BICEP Telescope for High-precision Cosmic Microwave Background Polarimetry 

      Takahashi, Yuki D.; Ade, Peter; Barkats, Denis; Battle, John O.; Bierman, Evan M.; Bock, James; Chiang, H. Cynthia; Dowell, C. Darren; Duband, Lionel; Hivon, Eric F.; Holzapfel, William L.; Hristov, Victor V.; Jones, William C.; Keating, Brian G.; Kovac, John M; Kuo, Chao-Lin; Lange, Andrew E.; Leitch, Erik M.; Mason, Peter V.; Matsumura, Tomotake; Nguyen, Hien T.; Ponthieu, N.; Pryke, Clement; Richter, Steffen; Rocha, Graca M.; Yoon, Ki Won (IOP Publishing, 2010)
      The Background Imaging of Cosmic Extragalactic Polarization (BICEP) experiment was designed specifically to search for the signature of inflationary gravitational waves in the polarization of the cosmic microwave background ...

    • Characterization of the Filum terminale as a neural progenitor cell niche in both rats and humans 

      Chrenek, Ryan; Magnotti, Laura M.; Herrera, Gabriella R.; Jha, Ruchira M.; Cardozo, David L. (John Wiley and Sons Inc., 2016)
      Abstract Neural stem cells (NSCs) reside in a unique microenvironment within the central nervous system (CNS) called the NSC niche. Although they are relatively rare, niches have been previously characterized in both the ...

    • Characterization of the functions and therapeutic potential of deubiquitinating enzymes in oncology 

      Doherty, Laura (2021-09-02)
      DUBs are dysregulated in cancer and other diseases, but there is much that is unknown about the specific substrates and pathways that individual DUBs regulate and their clinical utility remains incompletely explored. In ...

    • Characterization of the HD 17156 Planetary System 

      Barbieri, M.; Alonso, R.; Desidera, S.; Sozzetti, A.; Martinez Fiorenzano, A.F.; Almenara, J.M.; Cecconi, M.; Claudi, R.U.; Endl, M.; Granata, V.; Gratton, R.; Laughlin, G.; Loeillet, B.; Charbonneau, David (EDP Sciences, 2009)
      Aims. We present data to improve the known parameters of the HD 17156 system (peculiar due to the eccentricity and long orbital period of its transiting planet) and constrain the presence of stellar companions. Methods. ...

    • Characterization of the In Vivo Function of Neuropilin1 during Development 

      Gelfand, Maria (2013-02-20)
      Neuropilin1 (Npn1) is a transmembrane receptor that is critical for development of both the nervous and vascular systems. It is a ligand for both the chemorepulsive Semaphorin3s and for vascular endothelial growth factor ...

    • Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation 

      Mooij, Marlies J.; Drenkard, Eliana; Llamas, María A.; Vandenbroucke-Grauls, Christina M. J. E.; Savelkoul, Paul H. M.; Ausubel, Frederick M.; Bitter, Wilbert (Society for General Microbiology, 2007)
      Bacteriophages play an important role in bacterial virulence and phenotypic variation. It has been shown that filamentous bacteriophage Pf4 of Pseudomonas aeruginosa strain PAO1 mediates the formation of small-colony ...

    • Characterization of the Mamu-A*01-Restricted CD8-Positive T Lymphocyte Immunodominance Hierarchy in Simian Immunodeficiency Virus-Infected Rhesus Monkeys 

      Osuna-Gutierrez, Christa Elyse (2012-10-29)
      \(CD8^+\) cytotoxic T lymphocytes (CTLs) play a critical role in controlling human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. The CTL responses that are thought to be the most protective ...

    • Characterization of the Millimeter-Wave Polarization of Centaurus A with QUaD 

      Zemcov, Michael B.; Ade, Peter; Bock, James; Bowden, Melanie; Brown, Michael L.; Cahill, Gary; Castro, Patricia G.; Church, Sarah; Culverhouse, Thomas; Friedman, Robert B.; Ganga, Ken; Gear, Walter K.; Gupta, Sujata; Hinderks, James; Kovac, John M; Lange, Andrew E.; Leitch, Erik; Melhuish, Simon J.; Memari, Yasin; Murphy, J. Anthony; Orlando, Angiola; O’ Sullivan, Creidhe; Piccirillo, Lucio; Pryke, Clem; Rajguru, Nutan; Rusholme, Ben; Schwarz, Robert; Taylor, Andrew N.; Thompson, Keith L.; Turner, Abigail H.; Wu, Ed Y. S. (IOP Publishing, 2010)
      Centaurus (Cen) A represents one of the best candidates for an isolated, compact, highly polarized source that is bright at typical cosmic microwave background (CMB) experiment frequencies. We present measurements of the ...

    • Characterization of the OCO-2 instrument line shape functions using on-orbit solar measurements 

      Sun, Kang; Liu, Xiong; Nowlan, Caroline R.; Cai, Zhaonan; Chance, Kelly; Frankenberg, Christian; Lee, Richard A. M.; Pollock, Randy; Rosenberg, Robert; Crisp, David (European Geosciences Union, 2017)
      Accurately characterizing the instrument line shape (ILS) of the Orbiting Carbon Observatory-2 (OCO-2) is challenging and highly important due to its high spectral resolution and requirement for retrieval accuracy (0 : ...

    • Characterization of the planetary system Kepler-101 with HARPS-N - A hot super-Neptune with an Earth-sized low-mass companion 

      Bonomo, A. S.; Sozzetti, A.; Lovis, C.; Malavolta, L.; Rice, K.; Buchhave, L. A.; Sasselov, D.; Cameron, A. C.; Latham, D. W.; Molinari, E.; Pepe, F.; Udry, S.; Affer, L.; Charbonneau, D.; Cosentino, R.; Dressing, C. D.; Dumusque, X.; Figueira, P.; Fiorenzano, A. M.; Gettel, S.; Harutyunyan, A.; Haywood, R. D.; Horne, K.; Lopez-Morales, M.; Mayor, M.; Micela, G.; Motalebi, F.; Nascimbeni, V.; Phillips, D. F.; Piotto, G.; Pollacco, D.; Queloz, D.; Ségransan, D.; Szentgyorgyi, A.; Watson, C. (EDP Sciences, 2014)
      We characterize the planetary system Kepler-101 by performing a combined differential evolution Markov chain Monte Carlo analysis of Kepler data and forty radial velocities obtained with the HARPS-N spectrograph. This ...