Browsing Faculty of Arts and Sciences by Title
Now showing items 4503-4522 of 24540
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Defects in Hard-Sphere Colloidal Crystals
(2013-03-15)Colloidal crystals of \(1.55 \mu m\) diameter silica particles were grown on {100} and flat templates by sedimentation and centrifugation. The particles interact as hard spheres. The vacancies and divacancies in these ... -
Defending the Refutation of Idealism
(Southwestern Philosophical Society, 2000)In his Kant and the Claims of Knowledge, Paul Guyer offers an influential reading of Kant’s famous “Refutation of Idealism.” Guyer’s reading has been widely praised as Kantian exegesis but less favorably received as an ... -
A Defense of Traditional Hypotheses about the Term Structure of Interest Rates
(Blackwell Publishing, 1986)Expectations theories of asset returns may be interpreted either as stating that risk premia are zero or that they are constant through time. Under the former interpretation, different versions of the expectations theory ... -
Deferred Acceptance Algorithms: History, Theory, Practice, and Open Questions
(Springer, 2008)The deferred acceptance algorithm proposed by Gale and Shapley (1962) has had a profound influence on market design, both directly, by being adapted into practical matching mechanisms, and, indirectly, by raising new ... -
Deficient Heads and Long Head Movement in Slovak
(Michigan Slavic Publications, 1997)This paper examines verbal clitics in Polish and Slovak -
Define the RelationSHIP: INPP5D/SHIP1 regulates inflammasome activation in human microglia
(2022-09-09)Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). However, there are limitations to studying human microglia and utilizing mouse models to study microglia function. ... -
A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
(Frontiers Media SA, 2009)Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism ... -
A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays
(2016)Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum ... -
Defining a Role for T Regulatory Cell Expressed MyD88 During the Response to Allografts
(2015-11-16)The myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein proximally downstream of the Toll-like receptor (TLRs) and the IL-1 receptor family (IL-1R, IL- 18R and IL-33R). The TLR-MyD88 signaling ... -
Defining an “ideal” heritage speaker: Theoretical and methodological challenges | Reply to peer commentaries
(Walter de Gruyter, 2014-03-03) -
Defining Anabolic Functions of ATF4 as a Downstream Effector of mTORC1 Signaling
(2021-05-12)In response to a variety of upstream growth and oncogenic signals, the mechanistic target of rapamycin complex 1 (mTORC1) promotes anabolic metabolism, in part, through activation of downstream transcription factors. ... -
Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells
(2014-10-21)Acute myeloid leukemia (AML) is a clonal neoplastic disorder organized as a cellular hierarchy, with the self-renewing leukemia stem cell (LSC) at the apex. Recurrent mutations in transcription factors (TF) and epigenetic ... -
Defining Difference: The Role of Immigrant Generation and Race in American and British Immigration Studies
(Informa UK Limited, 2014)This article reviews the ways in which Britain and the USA classify and analyse the integration of immigrants and their descendants. While both societies recognize racial differences in their official statistics and in the ... -
Defining Diversity: Professionals and Institutionalization Processes
(2015-01-23)This dissertation is a qualitative study of the field of corporative diversity management, based on in-depth interviews with diversity managers and human resource managers at 87 firms across the United States. My work ... -
Defining Female Achievement: Gender, Class, and Work in Contemporary Korea
(2018-05-11)Understanding how women transition to adulthood and make decisions about family, employment, and parenting have long been central questions in gender and family scholarship. Korea offers a particularly compelling context ... -
Defining markers and mechanisms of human somatic cell reprogramming
(2014-02-25)Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by over expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Using serial live cell immunofluorescence imaging of human fibroblasts ... -
Defining the biochemical functions of the TSC complex and its regulation of Rheb-mTORC1 signaling
(2023-05-12)Nutrients and growth factors are sensed by a ubiquitous signaling network that converges on the protein kinase complex mechanistic target of rapamycin (mTOR) complex 1 (mTORC1). mTORC1 functions to integrate a diverse set ... -
Defining the crosstalk between the transcription and splicing machineries
(2024-03-12)Production of mammalian messenger RNAs (mRNAs) often requires RNA Polymerase II (RNAPII) to transcribe tens of kilobases and coordinate the co-transcriptional removal of multiple introns by the spliceosome. The expansion ... -
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ... -
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(Elsevier BV, 2016)Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated ...