Browsing Faculty of Arts and Sciences by Title
Now showing items 4887-4906 of 24540
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Development of Methods for Protein Delivery and the Directed Evolution of Recombinases
(2014-10-22)As a class, protein-based therapeutics offer tremendous advantages over traditional small molecule drugs. Due to their sizes and folding energies, proteins are ideal for catalyzing chemical reactions, and can bind tightly ... -
Development of Methods that Mimic, Measure, and Detect Evasion of the Adaptive Immune System
(2021-10-27)The ability of the adaptive immune system to generate incredible genetic diversity in response to environmental stimuli provides both a unique challenge to develop methods that can comprehensively analyze immune repertoires, ... -
Development of molecular glue degraders as probes and therapeutic agents
(2023-05-12)Development of molecular glue degraders as probes and therapeutic agents Immunomodulatory drugs (IMiDs) function as molecular glues between the E3 ligase substrate receptor cereblon (CRBN) and protein substrates. The ... -
Development of New Tools for Single-Molecule Force Spectroscopy & The Application of these Tools to Mapping the Role of Force Directionality in the Actin Mechanome
(2015-09-28)Actin filaments serve as a hub of focal adhesion-based mechanotransduction network in a wide variety of cell types. In this role filaments and networks of filaments are exposed to forces in a range of directions and ... -
The Development of Novel Spectroscopic Tools to Probe Free Radical Chemistry in the Troposphere
(2016-05-17)The oxidizing capacity of the atmosphere regulates both the longwave and shortwave radiation budgets holding our planet in equilibrium. As planetary conditions continue to shi , insights into the oxidation pathways determining ... -
Development of nucleic acid detection methods for object provenance and viral diagnostics
(2021-11-16)Starting with the discovery of DNA structure, advances in molecular and systems biology in the past few decades have propelled nucleic acid amplification and detection technologies with far-reaching applications including ... -
Development of photonic crystal cavities to enhance point defect emission in silicon carbide
(2017-09-07)Silicon carbide (SiC) is a semiconductor with a long history of use in a range of fields, finding applications in optoelectronics, high-power electronic devices (like field-effect transistors), and microelectromechanical ... -
The Development of Political Activists: A Model of Early Learning
(Wiley-Blackwell, 1986)An analysis of panel data reveals the unique importance of early learning to the development of political activism among Americans. A combination of two learning models-- the frequently used crystallization model and the ... -
Development of potent in vivo mutagenesis plasmids with broad mutational spectra
(Nature Pub. Group, 2015)Methods to enhance random mutagenesis in cells offer advantages over in vitro mutagenesis, but current in vivo methods suffer from a lack of control, genomic instability, low efficiency and narrow mutational spectra. Using ... -
The Development of Reasoning About Beliefs: Fact, Preference, and Ideology
(Elsevier BV, 2013)The beliefs people hold about the social and physical world are central to self-definition and social interaction. The current research analyzes reasoning about three kinds of beliefs: those that concern matters of fact ... -
Development of Redox Organics for Aqueous Flow Batteries
(2021-07-12)The cost of solar and wind electricity has dropped so precipitously that the main barrier to their widespread adoption is their intrinsic intermittency. Aqueous organic redox flow batteries (AORFBs) provide a potentially ... -
Development of Sensitivity to Geometry in Visual Forms
(Springer Verlag, 2009)Geometric form perception has been extensively studied in human children, but it has not been systematically characterized from the perspective of formal geometry. Here, we present the findings of three experiments that ... -
The Development of Sex Differences in Digital Formula from Infancy in the Fels Longitudinal Study
(Royal Society, The, 2005)Relative finger lengths, especially the second-to-fourth finger length ratio, have been proposed as useful markers for prenatal testosterone action. This claim partly depends on an association of relative finger lengths ... -
Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ... -
Development of the Corticospinal and Callosal Tracts from Extremely Premature Birth up to 2 Years of Age
(Public Library of Science, 2015)White matter tracts mature asymmetrically during development, and this development can be studied using diffusion magnetic resonance imaging. The aims of this study were i. to generate dynamic population-averaged white ... -
Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
(2014-10-21)Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word ... -
Development of the first-mention bias
(Cambridge University Press (CUP), 2014)In many contexts, pronouns are interpreted as referring to the character mentioned first in the previous sentence, an effect called the ‘first-mention bias’. While adults can rapidly use the first-mention bias to guide ... -
Development of Tin(II) Sulfide Solar Cells by Interface Engineering and Absorber Alloying
(2017-05-12)Tin(II) sulfide (SnS) is a promising candidate for alternative photovoltaic (PV) materials. Composed of cheap, non-toxic and earth-abundant elemental constituents, SnS has appropriate band gap and high absorption coefficient. ... -
Development, Aircraft Integration, and Field Deployment of a CO2 Herriott Cell to Measure Arctic Carbon Fluxes
(2017-01-13)The warming of the Arctic, as mediated by climate change, will precipitate a feedback effect. Should the carbon in soil be processed and emitted as the greenhouse gases CO2 and CH4, the feedback effect will be positive; ...