Browsing Faculty of Arts and Sciences by Title
Now showing items 5186-5205 of 24540
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Discovering How Youth Psychotherapies Work: Three Approaches to Identifying Mediators of Treatment Outcome
(2017-07-06)Although a lot is known about which psychotherapies work, surprisingly little is known about how they work. Understanding the processes and mechanisms through which evidence-based psychotherapies (EBPs) improve outcomes ... -
Discovering Latent Network Structure in Point Process Data
(Journal of Machine Learning Research, 2014)Networks play a central role in modern data analysis, enabling us to reason about systems by studying the relationships between their parts. Most often in network analysis, the edges are given. However, in many systems it ... -
Discovering Novel Feedback and Crosstalk Mechanisms in Cellular Signaling Pathways
(2013-09-04)Multiple signaling pathways control cellular response to environmental cues such as nutrients, growth factors and stress. Interpretation of these cues requires coordinated regulation of intracellular signaling pathways. ... -
Discovering Shared Cardiovascular Dynamics within a Patient Cohort
(Institute of Electrical and Electronics Engineers, 2012)Cardiovascular variables such as heart rate (HR) and blood pressure (BP) are robustly regulated by an underlying control system. Time series of HR and BP exhibit distinct dynamical patterns of interaction in response to ... -
Discovering Shared Dynamics in Physiological Signals: Application to Patient Monitoring in ICU
(Institute of Electrical and Electronics Engineers, 2012)Modern clinical databases include time series of vital signs, which are often recorded continuously during a hospital stay. Over several days, these recordings may yield many thousands of samples. In this work, we explore ... -
Discovering Structure in the Moral Domain
(2015-05-18)Early moral psychologists identified the moral domain with a class of actions that negatively impacted the wellbeing of others or violated their rights. However, anthropological work suggested that this view failed to ... -
Discovery and Atmospheric Characterization of Giant Planet Kepler-12b: An Inflated Radius Outlier
(American Astronomical Society, 2011)We report the discovery of planet Kepler-12b (KOI-20), which at 1.695 +/- 0.030 R-J is among the handful of planets with super-inflated radii above 1.65 R-J. Orbiting its slightly evolved G0 host with a 4.438 day period, ... -
Discovery and biological characterization of geranylated RNA in bacteria
(Nature Publishing Group, 2012)A general mass spectrometry-based screen for unusually hydrophobic cellular small-molecule RNA conjugates revealed geranylated RNA in E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, and Salmonella thyphimurium. ... -
Discovery and characterization of a novel dsRNA virus infecting the human parasite Trichomonas vaginalis
(2022-08-30)Trichomonas vaginalis is the most common non-viral cause of sexually transmitted infections around the world. Infection by this protozoan parasite results in trichomoniasis, a clinical inflammatory disease with acute and ... -
Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo
(American Chemical Society (ACS), 2015)The in efficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ... -
Discovery and Characterization of an Antimicrobial Toxin of the Gut Symbiont Bacteroides fragilis
(2018-08-17)The gut microbiota represents one of most densely populated ecosystems on earth. The trillions of bacteria that populate the gastrointestinal tract carry out essential tasks for the host, such as harvesting energy from ... -
The Discovery and Characterization of Endosomal Escape Enhancing Compounds to Improve Protein Delivery Efficacy
(2015-07-23)The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ... -
The Discovery and Characterization of NAD-Linked RNA
(2012-09-13)Over the past few decades, RNA has emerged as much more than just an intermediary in biology’s central dogma. RNA is now known to play a variety of catalytic, regulatory and defensive roles in living systems as demonstrated ... -
Discovery and Characterization of Novel Bioactive Peptides and a Natural ERRalpha Ligand
(2013-10-17)Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not ... -
Discovery and Characterization of Novel smORF-Encoded Polypeptides (SEPs)
(2016-01-04)Peptides and small proteins have essential physiological roles including metabolism (insulin), sleep (orexin), and stress (corticotropin-releasing hormone). Recent exploration of the human genome and proteome has revealed ... -
Discovery and Characterization of the Cylindrocyclophane Biosynthetic Pathway
(2016-05-17)Nature constructs structurally diverse, bioactive molecules using enzymes. Many enzymes catalyze synthetically challenging reactions under mild, physiological conditions. Consequently, they have long been a source of ... -
Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases
(2016-08-31)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as first-line defenders against intracellular pathogens. Their functions are dictated by germline-encoded activating and inhibitory ... -
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ... -
Discovery and Development of Novel Deubiquitinase Inhibitors via Parallel High-Throughput Screening
(2022-11-23)Ubiquitination is a critical post-translational modification in cell biology which results in a myriad of functional outcomes including proteasomal degradation of substrate proteins. The regulation of protein homeostasis ... -
Discovery and Functional Interpretation of Genetic Risk in Autoimmune Diseases
(2015-05-08)Autoimmune diseases are chronic and debilitating conditions arising from abnormal immune responses directed against normal body tissues; they collectively affect the lives of 5-10% of the world population. These diseases ...