Now showing items 5217-5236 of 24465

    • Discovery of near-ultraviolet counterparts to millisecond pulsars in the globular cluster 47 Tucanae 

      Rivera-Sandoval, L. E.; van den Berg, Maureen C.; Heinke, C. O.; Cohn, H. N.; Lugger, P. M.; Freire, P.; Anderson, J.; Serenelli, A. M.; Althaus, L. G.; Cool, A. M.; Grindlay, Jonathan E.; Edmonds, P. D.; Wijnands, R.; Ivanova, N. (Oxford University Press (OUP), 2015)
      We report the discovery of the likely white dwarf companions to radio millisecond pulsars 47 Tuc Q and 47 Tuc S in the globular cluster 47 Tucanae. These blue stars were found in near-ultraviolet images from the Hubble ...
    • Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome 

      Homan, Edwin (2013-02-19)
      The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ...
    • Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics 

      Li, Yen-Der (2023-05-03)
      Targeted protein degradation has emerged as a promising therapeutic approach that recruits cellular degradation machineries to induce degradation of target proteins. However, the mechanisms underlying many small molecule ...
    • Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa 

      Stremlau, Matthew H.; Andersen, Kristian G.; Folarin, Onikepe A.; Grove, Jessica N.; Odia, Ikponmwonsa; Ehiane, Philomena E.; Omoniwa, Omowunmi; Omoregie, Omigie; Jiang, Pan-Pan; Yozwiak, Nathan L.; Matranga, Christian B.; Yang, Xiao; Gire, Stephen K.; Winnicki, Sarah; Tariyal, Ridhi; Schaffner, Stephen F.; Okokhere, Peter O.; Okogbenin, Sylvanus; Akpede, George O.; Asogun, Danny A.; Agbonlahor, Dennis E.; Walker, Peter J.; Tesh, Robert B.; Levin, Joshua Z.; Garry, Robert F.; Sabeti, Pardis C.; Happi, Christian T. (Public Library of Science, 2015)
      Next-generation sequencing (NGS) has the potential to transform the discovery of viruses causing unexplained acute febrile illness (UAFI) because it does not depend on culturing the pathogen or a priori knowledge of the ...
    • Discovery of Radio Afterglow from the Most Distant Cosmic Explosion 

      Chandra, Poonam; Frail, Dale A.; Fox, Derek; Kulkarni, Shrinivas; Berger, Edo; Cenko, S. Bradley; Bock, Douglas C.-J.; Harrsion, Fiona; Kasliwal, Mansi (IOP Publishing, 2010)
      We report the discovery of radio afterglow emission from the gamma-ray burst GRB 090423, which exploded at a redshift of 8.3, making it the object with the highest known redshift in the Universe. By combining our radio ...
    • Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma 

      Hideshima, Teru; Qi, Jun; Paranal, Ronald; Tang, Weiping; Greenberg, Edward; West, Nathan; Colling, Meaghan; Estiu, Guillermina; Mazitschek, Ralph; Perry, Jennifer; Ohguchi, Hiroto; Cottini, Francesca; Mimura, Naoya; Güllü Görgün; Tai, Yu-Tzu; Richardson, Paul; Carrasco, Ruben; Wiest, Olaf; Schreiber, Stuart; Anderson, Kenneth; Bradner, James (National Academy of Sciences, 2016)
      Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib ...
    • The Discovery of Slowness in Music 

      Rehding, Alexander (Fordham University Press, 2015)
    • Discovery of Small-Molecule Autophagy Modulators in Mammalian Systems 

      Kuo, Szu-Yu (2016-06-07)
      Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which involves the formation of double-membrane vesicles that enclose cellular components and fuse with lysosomes. Autophagy is critical to the ...
    • Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death 

      Adams, Drew J.; Boskovic, Zarko; Theriault, Jimmy R.; Wang, Alex J.; Stern, Andrew M.; Wagner, Bridget K.; Shamji, Alykhan Farid; Schreiber, Stuart L. (American Chemical Society, 2013)
      Elevation of reactive oxygen species (ROS) levels has been observed in many cancer cells relative to nontransformed cells, and recent reports have suggested that small-molecule enhancers of ROS may selectively kill cancer ...
    • Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway 

      Schaefer, Giannina I.; Perez, José R.; Duvall, Jeremy R.; Stanton, Benjamin Z.; Shamji, Alykhan F.; Schreiber, Stuart L. (American Chemical Society, 2013)
      The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which ...
    • Discovery of smoking-related biomarkers for advanced treatment in non-small cell lung cancer (NSCLC) 

      Wang , Xinan (2022-03-17)
      Lung cancer is one of the most diagnosed cancers and the leading cause of cancer death globally. Up to 60% of the non-small cell lung cancer lung (NSCLC) cancer patients are diagnosed with distant metastases with a poor ...
    • Discovery of the Very Red Near-Infrared and Optical Afterglow of the Short-Duration Grb 070724a 

      Berger, Edo; Cenko, S. B.; Fox, D. B.; Cucchiara, A. (IOP Publishing, 2009)
      We report the discovery of the near-infrared and optical afterglow of the short-duration gamma-ray burst GRB 070724A. The afterglow is detected in iJHKs observations starting 2.3 hr after the burst with Ks = 19.59± 0.16 ...
    • Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) 

      Tan, Li; Nomanbhoy, Tyzoon; Gurbani, Deepak; Patricelli, Matthew; Hunter, John; Geng, Jiefei; Herhaus, Lina; Zhang, Jianming; Pauls, Eduardo; Ham, Youngjin; Choi, Hwan Geun; Xie, Ting; Deng, Xianming; Buhrlage, Sara J.; Sim, Taebo; Cohen, Philip; Sapkota, Gopal; Westover, Kenneth D.; Gray, Nathanael S. (American Chemical Society, 2014)
      We developed a pharmacophore model for type II inhibitors that was used to guide the construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library resulted in the identification of a ...
    • Discovery of Water Maser Emission in Eight AGNs with 70 m Antennas of NASA’s Deep Space Network 

      Kondratko, P. T.; Greenhill, Lincoln Jared; Moran, James M.; Lovell, J. E. J.; Kuiper, T. B. H.; Jauncey, D. L.; Cameron, L. B.; Gomez, J. F.; Garcia‐Miro, C.; Moll, E.; de Gregorio‐Monsalvo, I.; Jimenez‐Bailon, E. (IOP Publishing, 2006)
      We report the discovery of water maser emission in eight active galactic nuclei (AGN) with the 70-m NASA Deep Space Network (DSN) antennas at Tidbinbilla, Australia and Robledo, Spain. The positions of the newly discovered ...
    • Discovery of Water Maser Emission in Five AGNs and a Possible Correlation Between Water Maser and Nuclear 2–10 keV Luminosities 

      Kondratko, Paul T.; Greenhill, Lincoln Jared; Moran, James M. (IOP Publishing, 2006)
      We report the discovery of water maser emission in five active galactic nuclei (AGN) with the 100-m Green Bank Telescope (GBT). The positions of the newly discovered masers, measured with the VLA, are consistent with the ...
    • Discovery of widespread GTP-binding motifs in genomic DNA and RNA 

      Curtis, Edward A.; Liu, David Ruchien (Elsevier BV, 2013)
      Biological RNAs that bind small-molecules have been implicated in a variety of regulatory and catalytic processes. Inspired by these examples, we used in vitro selection to search a pool of genomeencoded RNA fragments for ...
    • Discrete Differential Geometry and Physics of Elastic Curves 

      McCormick, Andrew Grady (2013-10-17)
      We develop a general computational model for a elastic rod which allows for extension and shear.
    • Discrete genetic modules are responsible for complex burrow evolution in Peromyscus mice 

      Weber, Jesse N.; Peterson, Brant K.; Hoekstra, Hopi E. (Nature Publishing Group, 2013)
      Relative to morphological traits, we know little about how genetics influence the evolution of complex behavioural differences in nature1. It is unclear how the environment influences natural variation in heritable behaviour, ...
    • Discrete One-forms on Meshes and Applications to 3D mesh Parameterization 

      Gortler, Steven; Gotsman, Craig; Thurston, Dylan (Elsevier, 2006)
      We describe how some simple properties of discrete one-forms directly relate to some old and new results concerning the parameterization of 3D mesh data. Our first result is an easy proof of Tutte's celebrated “spring-embedding” ...
    • Discrete Single-Photon Quantum Walks with Tunable Decoherence 

      Broome, M. A.; Fedrizzi, A.; Lanyon, B. P.; Kassal, Ivan; Aspuru-Guzik, Alan; White, A. G. (American Physical Society, 2010)
      Quantum walks have a host of applications, ranging from quantum computing to the simulation of biological systems. We present an intrinsically stable, deterministic implementation of discrete quantum walks with single ...