Browsing Faculty of Arts and Sciences by Title
Now showing items 6523-6542 of 24540
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Engineering High-Precision CRISPR-Cas9 Nuclease and Base Editor Technologies
(2018-05-16)The human genome, comprising approximately three billion nucleotides separated across 23 chromosomes, contains a vast amount of sequence space encoding instructions for the production of RNA and protein molecules that make ... -
Engineering in Vitro Human Induced Pluripotent Stem Cell-Derived Brain Cell Models for Alzheimer’s Disease and Down Syndrome
(2018-09-25)In disease biology, animal models are widely used. By offering insights on disease etiology, they allow us to systematically examine the complexity of a disease and its mechanisms. However, over the last decade, failures ... -
Engineering Ingenium: Improving Engagement and Accuracy With the Visualization of Latin for Language Learning
(2015-04-08)The goal of Ingenium is to prompt beginning Latin students to think consciously and critically on Latin grammar prior to translating a sentence, while engaging them with the grammar in an intuitive and hands-on way. Learners ... -
Engineering microbial rhodopsins to expand the optogenetic toolkit
(2014-10-21)Cellular lipid membranes can – and often do – support a transmembrane electric field, serving as biological capacitors that maintain a voltage difference between their two sides. It isn't hard to see why these ... -
Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR
(2016)Recurrent, reciprocal genomic disorders resulting from non-allelic homologous recombination (NAHR) between near-identical segmental duplications (SDs) are a major cause of human disease, often producing phenotypically ... -
Engineering Molecules, Mineralization and Magnetism in Biology by Directed Evolution and Computation
(2017-01-26)The intersection of synthetic biology with physics and computer science generates rich opportunities for both advancing our understanding of biological entities and systems as well as engineering biology to address a variety ... -
Engineering Nanobody Intracellular Behavior Through Framework Mutagenesis
(2021-09-08)Antibodies and their derived fragments have traditionally been used to probe, neutralize, or interrogate primarily extracellular targets in living systems. While efforts have been taken to adapt the antigen-binding portions ... -
Engineering of Allosteric Transcription Factors and Their Use for Metabolic Pathway Evolution
(2016-01-27)Microbial metabolic production is an attractive alternative to traditional chemical synthesis for a wide array of commercially relevant molecules. Coaxing microbes to produce a target chemical efficiently often requires ... -
Engineering Plasmonic Waves in Two-Dimensional Electron Systems
(2015-05-08)Plasmonic waves are waves of mobile charge carriers caused by their collective oscillations. They can be excited in solid-state conducting materials and behave distinctively in different numbers of dimensions. With fabrication ... -
Engineering Protease Activity Sensors and Machine Learning Methods to Detect and Characterize Disease
(2021-05-11)Precision medicine promises the ability to intelligently tailor clinical interventions to individual patient needs. Personalizing clinical management will necessitate access to high quality, accurate, and functional ... -
Engineering Quantum Optical Matter: Defects, Entanglement, and Chemical Reactivity
(2022-04-25)The discovery of quantum theory has led to explanations for nearly all physical phenomena from the smallest to largest length scales. In recent decades, as quantum theories have become better understood, scientists and ... -
Engineering Quantum Optical Phenomena with Near-Zero Index Metamaterials
(2023-05-17)We theoretically and numerically demonstrate enhanced extended superradiance using a diamond epsilon near-zero (ENZ) metamaterial design. Due to the large spatial coherence in this metamaterial we experience an ultra-high ... -
Engineering Replication Defective Herpes Simplex Virus 1 Vectors for the Treatment of Cancer
(2021-11-16)Although immunotherapies, including virotherapy, have had clinical success in treating cancer over the past few years, certain patients do not respond to these treatments and others ultimately relapse or experience ... -
Engineering Shadows to Fabricate Optical Metasurfaces
(American Chemical Society (ACS), 2014)Optical metasurfaces—patterned arrays of plasmonic nanoantennas that enable the precise manipulation of light–matter interactions—are emerging as critical components in many nanophotonic materials, including planar ... -
Engineering superfluidity in Bose-Fermi mixtures of ultracold atoms
(American Physical Society (APS), 2005)We investigate many-body phase diagrams of atomic boson-fermion mixtures loaded in the two-dimensional optical lattice. Bosons mediate an attractive, finite-range interaction between fermions, leading to fermion pairing ... -
Engineering the control of mosquito-borne infectious diseases
(BioMed Central, 2014)Recent advances in genetic engineering are bringing new promise for controlling mosquito populations that transmit deadly pathogens. Here we discuss past and current efforts to engineer mosquito strains that are refractory ... -
Engineering the Epigenetic Regulatory Networks of T Cell Exhaustion and Embryonic Stem Cell Differentiation with Transcription Factor Perturbations
(2024-03-12)The complex interplay of epigenetic factors including chromatin remodeling, histone modifications, and transcription factor binding regulate gene expression and therefore give rise to the diversity of cells within the human ... -
Engineering the excitonic and photonic properties of atomically thin semiconductors
(2023-01-04)Atomically thin and layered semiconductors are of broad interest to the physics and engineering communities in the past decade. As true members of the mesoscale, such materials have exotic and potentially advantageous ... -
Engineering whole-body gene therapies for aging
(2023-05-15)In the past 30 years, significant progress has been made in understanding the biological and genetic processes of aging, with over 300 genes now known to modulate lifespan. Many of these genes are expressed ubiquitously ... -
English for “Biblioteche: l’architettura e l’ordinamento del sapere,”
(Angelo Colla Editore, 2010)