Browsing Faculty of Arts and Sciences by Title
Now showing items 744-763 of 24540
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Als wär’ es ein Stuck von uns . . . German Politics and Society Traverses Twenty Years of United Germany
(Berghahn Journals, 2010)This essay looks at postunification Germany through the pages of German Politics and Society. The articles published during this period reveal the evolution of intellectuals' understanding of the unified country—concerns ... -
ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
(2015)The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to ... -
ALS-Implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Repair
(Springer Nature, 2019-01-14)The discovery that TDP-43 mutations cause familial ALS and that many patients display pathological TDP-43 mislocalization has nominated altered RNA metabolism as a potential disease mechanism. Despite its importance, the ... -
The ALS-Linked Gene TDP-43 Regulates \(IFN\beta\) Expression through a Novel Mechanism of 3' UTR-Mediated Promoter cis-Regulation
(2013-03-20)The TAR DNA-binding protein (TDP-43) is a heterogeneous nuclear ribonucleprotein that is involved in multiple stages of RNA processing. Mutations in the TDP-43 gene and mislocalization of TDP-43 protein have been implicated ... -
Alterations in Energy Metabolism and Neurodegeneration as a Conseqeunce of DNA Damage
(2017-01-18)The correlation between DNA damage and aging has been discussed since Peter Medawar framed the first modern theory of aging in 1952. In support of a causal relationship between DNA damage and aging, most human segmental ... -
Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model
(Nature Publishing Group, 2016)Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have ... -
Altered intrinsic functional coupling between core neurocognitive networks in Parkinson's disease
(Elsevier, 2015)Parkinson's disease (PD) is largely attributed to disruptions in the nigrostriatal dopamine system. These neurodegenerative changes may also have a more global effect on intrinsic brain organization at the cortical level. ... -
Alternate Compactifications of Hurwitz Spaces
(2012-12-19)We construct several modular compactifications of the Hurwitz space \(H^d_{g/h}\) of genus g curves expressed as d-sheeted, simply branched covers of genus h curves. They are obtained by allowing the branch points of the ... -
Alternate structures regulate transcription and translation of RNA viral genomes
(2022-06-06)With the emergence of new RNA-structure related techniques, it is becoming increasingly clear that viral RNA genomes are structurally and functionally plastic, which drive multiple phases of the viral lifecycle. My doctoral ... -
Alternating layer addition approach to CdSe/CdS core/shell quantum dots with near-unity quantum yield and high on-time fractions
(Royal Society of Chemistry (RSC), 2012)We report single-particle photoluminescence (PL) intermittency (blinking) with high on-time fractions in colloidal CdSe quantum dots (QD) with conformal CdS shells of 1.4 nm thickness, equivalent to approximately 4 CdS ... -
Alternating selection for dispersal and multicellularity favors regulated life cycles
(2023-05-02)The evolution of complex multicellularity opened paths to increased morphological diversity and organizational novelty. This transition involved three processes: cells remained attached to one another to form groups, cells ... -
An Alternative Conception of Tree-Adjoining Derivation
(MIT Press, 1994)The precise formulation of derivation for tree-adjoining grammars has important ramifications for a wide variety of uses of the formalism, from syntactic analysis to semantic interpretation and statistical language modeling. ... -
An alternative conception of tree-adjoining derivation
(Association for Computational Linguistics, 1992)The precise formulation of derivation for tree-adjoining grammars has important ramifications for a wide variety of uses of the formalism, from syntactic analysis to semantic interpretation and statistical language modeling. ... -
Alternative Histories of the White Cube: European Modernism and Mediterranean Vernacular
(2022-04-13)This dissertation investigates historical formulations of the white cube as a link between European modernism and Mediterranean vernacular. Architectural history consistently presents white and cubical modernist designs ... -
Alternative Models for Moment Inequalities
(Econometric Society, 2010)Behavioral choice models generate inequalities which, when combined with additional assumptions, can be used as a basis for estimation. This paper considers two sets of such assumptions and uses them in two empirical ... -
Alternative Splicing Regulation in Programmed Cell Death and Neurological Disorders: A Systems Biology Approach
(2013-09-30)Alternative splicing (AS) is a major source of biological diversity and a crucial determinant of cell fate and identity. Characterizing the role of AS regulatory networks in physiological and pathological processes remains ... -
An Alternative to Ceremonial Negligence (Catullus 68.73-78)
(Harvard University Press, 1978) -
always extra folds: A Composition Portfolio
This portfolio dissertation brings together a selection of the musical work I produced over seven years (2013–20). My work during this time evolved to embrace new modes of engaging with performers and audiences. I sought ... -
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect
(Frontiers Media S.A., 2015)Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) ... -
Amazon Forest Response to Changes in Rainfall Regime: Results from an Individual-Based Dynamic Vegetation Model
(2014-02-25)The Amazon is the largest tropical rainforest in the world, and thus plays a major role on global water, energy, and carbon cycles. However, it is still unknown how the Amazon forest will respond to the ongoing changes ...