Browsing Faculty of Arts and Sciences by Title
Now showing items 8665-8684 of 24540
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Functional characterization of genetic variation with in silico predictions of cell-type-specific regulatory elements
(2020-09-10)Genome-wide association studies (GWAS) have implicated thousands of complex trait-variant associations, an estimated 90% of which reside in the noncoding genome. While noncoding variants generally have poorly understood ... -
Functional Characterization of mSWI/SNF Complexes using Perturb-seq
(2021-07-12)Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit chromatin remodeling machines that use the power derived from ATP hydrolysis to mobilize nucleosomes and facilitate chromatin accessibility. mSWI/SNF complexes ... -
Functional Characterization of Netrin-1 and Its Role in CNS-PNS Boundary Maintenance in the Developing Vertebrate Brainstem
(2018-05-01)Netrin-1 (Ntn1) has represented the archetype of diffusible guidance cues since its discovery in the 1990s. It is often depicted in a gradient emanating from the floor plate of the embryonic neural tube, through which it ... -
Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging
(2023-08-22)This dissertation describes my efforts towards a precise network-informed functional characterization of the human hippocampal long axis, made possible by advances in within-individual precision human neuroimaging. In the ... -
Functional circuit architecture underlying parental behaviour
(Springer Science and Business Media LLC, 2018-04)Parenting is essential for the survival and wellbeing of mammalian offspring but we lack a circuit-level understanding of how distinct components of this behaviour are orchestrated. Here we investigate how Galanin-expressing ... -
Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults
(Mary Ann Liebert, Inc., 2015)Abstract Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in large-scale cortical networks. This study examined multiple cortical networks using Template-Based Rotation (TBR), a ... -
Functional Connectivity in the First Year of Life in Infants at Risk for Autism Spectrum Disorder: An EEG Study
(Public Library of Science, 2014)In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants ... -
Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study
(Frontiers Media S.A., 2013)Background: Autism spectrum disorder (ASD) has been called a “developmental disconnection syndrome,” however the majority of the research examining connectivity in ASD has been conducted exclusively with older children and ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ... -
Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer
(2013-10-18)Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely ... -
Functional Development and Plasticity of Parvalbumin Cells in Visual Cortex: Role of Thalamocortical Input
(2013-03-15)Unlike principal excitatory neurons, cortical interneurons comprise a diverse group of distinct subtypes. They can be classified by their morphology, molecular content, developmental origins, electrophysiological properties ... -
Functional diversity among sensory receptors in a Drosophila olfactory circuit
(Proceedings of the National Academy of Sciences, 2013)The ability of an animal to detect, discriminate, and respond to odors depends on the function of its olfactory receptor neurons (ORNs), which in turn depends ultimately on odorant receptors. To understand the diverse ... -
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation
(The Company of Biologists, 2013)Embryonic stem (ES) cells hold great promise with respect to their potential to be differentiated into desired cell types. Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and ... -
Functional genomic dissection of human brain development, degeneration, and dysfunction in pediatric neurogenetic disorders
(2023-09-13)Human disease genetics has implicated hundreds of genes in brain development, maintenance, and function. Experimentally tractable animal models and culture systems have contributed greatly to understanding the function of ... -
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
(eLife Sciences Publications, Ltd, 2015)Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine ... -
Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling
(2013-10-15)Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic ... -
Functional Genomics at the EHEC-Intestinal Interface: Mechanisms of Pathogenicity and the Host Response
(2021-01-20)Enterohemorrhagic Escherichia coli (EHEC) is a human foodborne pathogen that infects the colon, leading to hemorrhagic colitis and the potentially fatal hemolytic uremic syndrome. This dissertation aims to address the ... -
The functional interplay between TNPO3, CPSF6 and HIV-1 CA
(2014-10-21)Lentiviruses can infect postmitotic cells, indicative of a role for the nucleocytoplasmic transport machinery. Genome-wide RNA interference screens identified transportin 3 (TNPO3) that may regulate human immunodeficiency ... -
Functional Materials Grown from Engineered Bacteria
(2021-07-12)Nature has produced living materials with wonderful properties, including the ability to self-regenerate, to sense and respond to a changing environment, and to harvest energy from the sun. Inspired by this, researchers ...