Now showing items 9033-9052 of 24465

    • A genomic and evolutionary approach reveals non-genetic drug resistance in malaria 

      Herman, Jonathan D; Rice, Daniel P; Ribacke, Ulf; Silterra, Jacob; Deik, Amy A; Moss, Eli L; Broadbent, Kate M; Neafsey, Daniel E; Desai, Michael M; Clish, Clary B; Mazitschek, Ralph; Wirth, Dyann F (BioMed Central, 2014)
      Background: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis ...
    • Genomic and Functional Studies of Uveal Melanoma 

      Place, Chelsea Schwartz (2015-05-05)
      Uveal melanoma (UM) is a rare form of melanoma that is lethal once metastatic. Primary tumors in the iris, ciliary body, and choroid of the eye metastasize in 50% of patients, despite effective treatment of the initial ...
    • Genomic Approaches to Dissect Innate Immune Pathways 

      Lee, Mark N (2013-03-14)
      The innate immune system is of central importance to the early containment of infection. When receptors of innate immunity recognize molecular patterns on pathogens, they initiate an immediate immune response by inducing ...
    • Genomic Citizenship: Peoplehood and State in Israel and Qatar 

      McGonigle, Ian (2018-05-08)
      This dissertation describes basic genetic research and biobanking of ethnic populations in Israel and Qatar. I track how biomedical research on ethnic populations relates to the political, economic, legal, and historical ...
    • Genomic drivers of distinct pediatric brain tumors: diffuse midline gliomas and adamantinomatous craniopharyngiomas 

      Khadka, Prasidda (2021-08-19)
      Pediatric brain tumors are distinct from their adult counterparts. This thesis examines genomic drivers of two distinct pediatric brain tumors: a fast growing and uniformly fatal diffuse midline glioma and a slower growing ...
    • Genomic Evidence of Gene Flow During Reinforcement in Texas Phlox 

      Roda, Federico; Mendes, Fabio; Hahn, Matthew W.; Hopkins, Robin (Wiley, 2017-03-06)
      Gene flow can impede the evolution of reproductive isolating barriers between species. Reinforcement is the process by which prezygotic reproductive isolation evolves in sympatry due to selection to decrease costly ...
    • Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in Heliconius erato 

      Counterman, Brian A.; Araujo-Perez, Felix; Hines, Heather M.; Baxter, Simon W.; Morrison, Clay M.; Lindstrom, Daniel P.; Papa, Riccardo; Ferguson, Laura; Joron, Mathieu; ffrench-Constant, Richard H.; Smith, Christopher P.; Nielsen, Dahlia M.; Chen, Rui; Jiggins, Chris D.; Reed, Robert D.; Halder, Georg; Mallet, James; McMillan, W. Owen (Public Library of Science (PLoS), 2010)
      Wing pattern evolution in Heliconius butterflies provides some of the most striking examples of adaptation by natural selection. The genes controlling pattern variation are classic examples of Mendelian loci of large effect, ...
    • Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade 

      Baxter, Simon W.; Nadeau, Nicola J.; Maroja, Luana S.; Wilkinson, Paul; Counterman, Brian A.; Dawson, Anna; Beltran, Margarita; Perez-Espona, Silvia; Ferguson, Laura; Davidson, Claire; Glithero, Rebecca; Mallet, James; Joron, Mathieu; ffrench-Constant, Richard H.; Jiggins, Chris D.; Chamberlain, Nicola L; Clark, Richard; McMillan, W. Owen; Kronforst, Marcus (Public Library of Science, 2010)
      Wing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection. The loci controlling such patterns are “hotspots” for adaptive evolution ...
    • Genomic imprinting and the evolutionary psychology of human kinship 

      Haig, David Addison (Proceedings of the National Academy of Sciences, 2011)
      Genomic imprinting is predicted to influence behaviors that affect individuals to whom an actor has different degrees of matrilineal and patrilineal kinship (asymmetric kin). Effects of imprinted genes are not predicted ...
    • Genomic Imprinting in the Brain: the persistent influences from Mom and Dad 

      Perez, Julio David (2015-05-20)
      Most mammalian genes are equally expressed from the two inherited parental alleles. However, a puzzling subgroup known as imprinted genes are preferentially expressed from either the maternally- or paternally-inherited ...
    • Genomic Imprinting Is Implicated in the Psychology of Music 

      Mehr, Samuel; Kotler, Jennifer; Howard, Rhea; Haig, David; Krasnow, Max (Center for Open Science, 2017-01-27)
      Why do people sing to babies? Human infants are relatively altricial and need their parents’ attention to survive. Infant-directed song may constitute a signal of that attention. In Prader-Willi syndrome (PWS), a rare ...
    • Genomic insights into bacterial adaptation during infection 

      Lieberman, Tami Danielle (2014-06-06)
      Bacteria evolve during the colonization of human hosts, yet little is known about the selective pressures and evolutionary forces that shape this evolution. Illumination of these processes may inspire new therapeutic ...
    • The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis 

      Gibson, William J.; Hoivik, Erling A.; Halle, Mari K.; Taylor-Weiner, Amaro; Cherniack, Andrew D.; Berg, Anna; Holst, Frederik; Zack, Travis I.; Werner, Henrica M. J.; Staby, Kjersti M.; Rosenberg, Mara; Stefansson, Ingunn M.; Kusonmano, Kanthida; Chevalier, Aaron; Mauland, Karen K.; Trovik, Jone; Krakstad, Camilla; Giannakis, Marios; Hodis, Eran; Woie, Kathrine; Bjorge, Line; Vintermyr, Olav K.; Wala, Jeremiah A.; Lawrence, Michael S.; Getz, Gad; Carter, Scott L.; Beroukhim, Rameen; Salvesen, Helga B. (2016)
      Recent studies have detailed the genomic landscape of primary endometrial cancers, but their evolution into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex ...
    • Genomic legacy of the African cheetah, Acinonyx jubatus 

      Dobrynin, Pavel; Liu, Shiping; Tamazian, Gaik; Xiong, Zijun; Yurchenko, Andrey A.; Krasheninnikova, Ksenia; Kliver, Sergey; Schmidt-Küntzel, Anne; Koepfli, Klaus-Peter; Johnson, Warren; Kuderna, Lukas F.K.; García-Pérez, Raquel; Manuel, Marc de; Godinez, Ricardo; Komissarov, Aleksey; Makunin, Alexey; Brukhin, Vladimir; Qiu, Weilin; Zhou, Long; Li, Fang; Yi, Jian; Driscoll, Carlos; Antunes, Agostinho; Oleksyk, Taras K.; Eizirik, Eduardo; Perelman, Polina; Roelke, Melody; Wildt, David; Diekhans, Mark; Marques-Bonet, Tomas; Marker, Laurie; Bhak, Jong; Wang, Jun; Zhang, Guojie; O’Brien, Stephen J. (BioMed Central, 2015)
      Background: Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations. Results: Here the genome sequence of wild-born African cheetahs ...
    • The genomic origins of the Bronze Age Tarim Basin mummies 

      Zhang, Fan; Ning, Chao; Scott, Ashley; Fu, Qiaomei; Bjørn, Rasmus; Li, Wenying; Wei, Dong; Wang, Wenjun; Fan, Linyuan; Abuduresule, Idilisi; Hu, Xingjun; Ruan, Qiurong; Niyazi, Alipujiang; Dong, Guanghui; Cao, Peng; Liu, Feng; Dai, Qingyan; Feng, Xiaotian; Yang, Ruowei; Tang, Zihua; Ma, Pengcheng; Li, Chunxiang; Gao, Shizhu; Xu, Yang; Wu, Sihao; Wen, Shaoqing; Zhu, Hong; Zhou, Hui; Robbeets, Martine; Kumar, Vikas; Krause, Johannes; Warinner, Christina; Jeong, Choongwon; Cui, Yinqiu (Springer Science and Business Media LLC, 2021-10-27)
      The identity of the earliest inhabitants of Xinjiang, in the heart of Inner Asia, and the languages that they spoke have long been debated and remain contentious. Here we present genomic data from 5 individuals dating to ...
    • Genomic Sequence is Highly Predictive of Local Nucleosome Depletion 

      Yuan, Guo-Cheng; Liu, Jun (Public Library of Science, 2008)
      The regulation of DNA accessibility through nucleosome positioning is important for transcription control. Computational models have been developed to predict genome-wide nucleosome positions from DNA sequences, but these ...
    • Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak 

      Gire, Stephen; Goba, A.; Andersen, Kristian G; Sealfon, R. S. G.; Park, D. J.; Kanneh, L.; Jalloh, S.; Momoh, M.; Fullah, M.; Dudas, G.; Wohl, Shirlee; Moses, L. M.; Yozwiak, Nathan; Winnicki, Sarah M.; Matranga, C. B.; Malboeuf, C. M.; Qu, J.; Gladden, Adrianne Deanna; Schaffner, Stephen; Yang, X.; Jiang, P.-P.; Nekoui, M.; Colubri, Andres; Coomber, M. R.; Fonnie, M.; Moigboi, A.; Gbakie, M.; Kamara, F. K.; Tucker, V.; Konuwa, E.; Saffa, S.; Sellu, J.; Jalloh, A. A.; Kovoma, A.; Koninga, J.; Mustapha, I.; Kargbo, K.; Foday, M.; Yillah, M.; Kanneh, F.; Robert, W.; Massally, J. L. B.; Chapman, S. B.; Bochicchio, J.; Murphy, C.; Nusbaum, C.; Young, S.; Birren, B. W.; Grant, D. S.; Scheiffelin, J. S.; Lander, Eric Steven; Happi, Christian Tientcha; Gevao, S. M.; Gnirke, A.; Rambaut, A.; Garry, R. F.; Khan, S. H.; Sabeti, Pardis Christine (American Association for the Advancement of Science (AAAS), 2014)
      In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid ...
    • Genomic Tools Reveal Changing Plasmodium falciparum Populations 

      Daniels, Rachel Fath (2013-09-25)
      A new era of malaria eradication programs relies on increased knowledge of the parasite through sequencing of the Plasmodium genome. Programs call for re-orientation at specific epidemiological markers as regions move from ...
    • Genomic vagabonds: Endogenous retroviruses and placental evolution 

      Haig, David Addison (Wiley-Blackwell, 2013)
    • Genomic variation and evolution of the human malaria parasite Plasmodium falciparum 

      Chang, Hsiao-Han (2013-10-08)
      Malaria is a deadly disease that causes nearly one million deaths each year. Understanding the demographic history of the malaria parasite Plasmodium falciparum and the genetic basis of its adaptations to antimalarial ...