Browsing Faculty of Arts and Sciences by Title
Now showing items 9834-9853 of 24540
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The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation
(Elsevier BV, 2014)The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in ... -
The Hippocampus and Imagining the Future: Where Do We Stand?
(Frontiers Research Foundation, 2012)Recent neuroimaging work has demonstrated that the hippocampus is engaged when imagining the future, in some cases more than when remembering the past. It is possible that this hippocampal activation reflects recombining ... -
The Hirbemerdon Tepe Archaeological Project 2008: A Preliminary Report
(Ministry of Culture and Tourism for Turkey, 2010) -
Hirzebruch's Proportionality Theorem in the Non-Compact Case
(Springer Verlag, 1977) -
The histone chaperone CAF-1 safeguards somatic cell identity
(2016)Cellular differentiation involves profound remodeling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory ... -
Histone Deacetylase 1 Phosphorylation Promotes Enzymatic Activity and Complex Formation
(American Society for Biochemistry and Molecular Biology, 2001)Accessibility of the genome to DNA-binding transcription factors is regulated by proteins that control the acetylation of amino-terminal lysine residues on nucleosomal histones. Specifically, histone deacetylase (HDAC) ... -
The histone demethylase LSD1/KDM1A promotes the DNA damage response
(The Rockefeller University Press, 2013)Histone demethylation is known to regulate transcription, but its role in other processes is largely unknown. We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR). We show that LSD1 is ... -
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA
(2014)ISWI-family remodelling enzymes regulate access to genomic DNA by mobilizing nucleosomes1. These ATP-dependent chromatin remodellers promote heterochromatin formation and transcriptional silencing1 by generating regularly-spaced ... -
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
(Nature Publishing Group, 2011) -
Histone variants and cellular plasticity
(Elsevier BV, 2015-09)The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular ... -
Historia in Theodor Zwinger's Theatrum Humanae Vitae
(MIT Press, 2005)One of the ways in which historia reached its widest audience in the Renaissance was in collections short passages excerpted from various historical sources and sorted under topical headings, often called exempla. The ... -
Historia Intelectual y Longue Durée. La Guerra Civil en Perspectiva Histórica
(Universidad del País Vasco, 2012)Resumen: Después de décadas de abandono, historiadores de todo tipo vuelven a ofrecer estudios de gran amplitud temporal. Hay signos de que los historiadores intelectuales están regresando incluso a la longue durée. ¿Cuáles ... -
The Historic Avant-Garde, the Neo-Avant-Garde and the Digital Age: Experimental Visual-Textual Forms in the Luso-Hispanic World
(2013-02-15)My dissertation examines the experimental poetry of three periods, the historical avant-garde of the 1920s, the neo-avant-gardes of the 1950s, 60s, and 70s, and the digital avant-garde (from the 1990s until the present), ... -
Historical Adaptability of U.S. Maize to Climate Change: A Reassessment
(2018-06-29)The threat that climate change poses on food security is accentuated by the fact that we need to increase our food supply in light of a growing global population and higher per capita demand. The prospect of these challenges ... -
Historical Biogeography and Diversification of Truffles in the Tuberaceae and Their Newly Identified Southern Hemisphere Sister Lineage
(Public Library of Science (PLoS), 2013)Truffles have evolved from epigeous (aboveground) ancestors in nearly every major lineage of fleshy fungi. Because accelerated rates of morphological evolution accompany the transition to the truffle form, closely related ... -
The historical evolution of female earnings functions and occupations
(Elsevier BV, 1984)Of all the changes in the history of women's market work, few have been more impressive than the rapid emergence and feminization of the clerical sector and the related decline in manufacturing employment for women. Although ... -
Historical Institutionalism in Rationalist and Sociological Perspective
(Cambridge University Press, 2010) -
Historical legacies: A model linking Africa's past to its current underdevelopment
(Elsevier BV, 2007)Recent studies have found evidence linking Africa’s current under-development to colonial rule and the slave trade. Given that these events ended long ago, why do they continue to matter today? I develop a model, exhibiting ... -
Historical Mercury Releases from Commercial Products: Global Environmental Implications
(American Chemical Society (ACS), 2014)The intentional use of mercury (Hg) in products and processes (“commercial Hg”) has contributed a large and previously unquantified anthropogenic source of Hg to the global environment over the industrial era, with major ...