Browsing Faculty of Arts and Sciences by Keyword "Alzheimer's disease"
Now showing items 1-9 of 9
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The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
(Oxford University Press, 2009)Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities ... -
Differential Effects of Aging and Alzheimer's Disease on Medial Temporal Lobe Cortical Thickness and Surface Area
(Elsevier, 2009)The volume of parcellated conical regions is a composite measure related to both thickness and surface area. It is not clear whether volumetric decreases in medial temporal lobe (MTL) cortical regions in aging and Alzheimer's ... -
Disruption of Mitochondrial Dynamics in Tauopathy
(2013-02-06)Alzheimer’s disease (AD) is characterized pathologically by proteinaceous aggregates composed primarily of amyloid \(\beta (A \beta)\) and tau. Diseases characterized by abnormal deposition of tau are collectively termed ... -
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
(2014-10-22)Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ... -
New methods of correlated light and electron microscopy provide a multi-molecular overlay for large-volume connectomic data in the brain
(2023-05-12)Mapping neuronal networks underlying behavior has become a central focus in neuroscience. Serial section electron microscopy (ssEM) is an approach that has been used to reveal the fine structure of synaptically connected ... -
Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study
(S. Karger AG, 2012)Background: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition ... -
The Role of the Human Tau 3'-Untranslated Region in Regulating Tau Expression
(2013-10-18)The microtubule-associated protein tau forms pathological neuronal filaments in Alzheimer's disease (AD) and other neurodegenerative disorders, known collectively as tauopathies. Previous studies in transgenic mouse models ... -
Statistical Characterization of Protein Ensembles
(2013-02-20)Conformational ensembles are models of proteins that capture variations in conformation that result from thermal fluctuations. Ensemble based models are important tools for studying Intrinsically Disordered Proteins (IDPs), ... -
Young systemic factors as a medicine for age-related neurodegenerative diseases
(Taylor & Francis, 2015)It is widely known that neurogenesis, brain function and cognition decline with aging. Increasing evidence suggests that cerebrovascular dysfunction is a major cause of cognitive impairment in the elderly but is also ...