Browsing Faculty of Arts and Sciences by Keyword "Biomedical engineering"
Now showing items 1-20 of 50
-
Airborne Disease Transmission via Bioaerosols: Formation Mechanisms and the Influence of Viscoelasticity
(2013-03-18)Airborne disease transmission is a prominent problem facing an increasingly mobilized world. It involves small droplets (bioaerosols) containing pathogens which form in the lungs and are expelled to the environment, where ... -
Antigen-specific immune modulation using an injectable biomaterial
(2014-06-06)The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific ... -
Biomaterial scaffold-based vaccines sustain robust immune responses through the lymph nodes
(2022-05-05)Emergent vaccine therapies aim to engineer the multi-scale interactions that naturally occur within lymph nodes (LNs), from cellular behavior to tissue dynamics. Therapeutic cancer vaccines have demonstrated safety and ... -
Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers
(2013-10-15)Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ... -
Complementary Metal-Oxide-Semiconductor (CMOS) Bio-electronic Interface for Cell-based Phenotypic Drug Screening
(2021-07-12)Microelectrode Array (MEA) has been widely researched and with some commercial usage in measuring electrical properties and behavior of cardiac and neuronal networks, thanks to its low cost and parallelism compared to ... -
Density-Based Separations in Aqueous Multiphase Systems: Tools for Biological Research and Low-Cost Diagnostics
(2014-06-06)Cells often exist in heterogeneous mixtures. Density provides a property to separate several types of cells from the mixed sample in which they originate. Density-based separation methods provide a standard method to ... -
Design and Assembly Considerations in the Engineering of Vascular Tissue
(2014-02-25)Native vascular tissue functions are highly dependent on structural organization at the super-cellular, cellular, and sub-cellular spatial scales. We hypothesized that the structure-function relationship of vascular tissues ... -
Design Considerations for Engineered Myocardium
(2014-06-06)The fabrication of biomimetic heart muscle suitable for pharmaceutical compound evaluation and disease modeling is hindered by limitations in our understanding of how to guide and assess the maturity of engineered myocardium ... -
Designing Scalable Biological Interfaces
(2014-06-06)This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but ... -
Designing Viscoelastic Bioelectronic Interfaces: From the Organ to Cell Scale
(2022-06-06)Living tissues are non-linearly elastic materials that exhibit viscoelasticity and plasticity. Man-made, implantable bioelectronic arrays mainly rely on thin films of ductile metals encapsulated by rigid plastic or hydrophobic ... -
Detection and Characterization of Autism Spectrum Disorder and Parkinson’s Disease Utilizing Measures of Speech- and Fine-Motor Coordination
(2023-05-02)Neurological disorders such as Autism Spectrum Disorder (ASD) and Parkinson’s Disease (PD) are typically associated with observed motor difficulties in speech production and in fine-motor tasks (including oculo-motor tasks), ... -
Development and Validation of Migration Assay for Cellular Backpacks Adhered to Human and Murine Monocytes for Targeted Drug-Delivery
(2022-06-03)The Mitragotri Lab has been developing immune cell-based therapies to improve drug targeting and accumulation, particularly to cross the blood-brain barrier for the treatment of traumatic brain injury. We use cellular ... -
Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
(2013-10-17)The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined ... -
Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
(2014-10-21)Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word ... -
Developmentally-Inspired Engineering Of An Inductive Biomaterial for Odontogenesis
(2014-06-06)Increasing demands for organ transplants and the depleting supply of available organs has heightened the need for alternatives to this growing problem. Tissue engineers strive to regenerate organs in the future; however ... -
Directed differentiation of mouse embryonic stem cells into neocortical output neurons
(2013-10-18)During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons ... -
Endothelial Progenitor Cell Recruitment for Therapeutic Neovascularization using Alginate Hydrogels for VEGF and SDF Delivery
(2014-06-06)Endothelial progenitor cells are potentially useful as a cell therapy for the treatment of ischemic cardiovascular diseases, but clinical outcomes have been limited likely because very few systemically delivered cells reach ... -
Enhanced Ultrasound Visualization for Procedure Guidance
(2014-06-06)Intra-cardiac procedures often involve fast-moving anatomic structures with large spatial extent and high geometrical complexity. Real-time visualization of the moving structures and instrument-tissue contact is crucial ... -
EVALUATION OF COCHLEAR IMPLANT (CI)-MEDIATED MUSIC PROCESSING USING ELECTRODOGRAM MAPPING TO COMPARE WITH PERCEPTION
(2021-06-17)Appreciating and perceiving music has been a persistent challenge for using cochlear implants (CIs). Despite having speech perception capabilities in quiet environments, CI users struggle with foundational components of ... -
EVALUATION OF COCHLEAR IMPLANT (CI)-MEDIATED MUSIC PROCESSING USING ELECTRODOGRAM MAPPING TO COMPARE WITH PERCEPTION
(2021-06-17)Appreciating and perceiving music has been a persistent challenge for using cochlear implants (CIs). Despite having speech perception capabilities in quiet environments, CI users struggle with foundational components of ...