Browsing Faculty of Arts and Sciences by Keyword "Biophysics"
Now showing items 1-20 of 116
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3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing
(Public Library of Science, 2012)The connectivity among neurons holds the key to understanding brain function. Mapping neural connectivity in brain circuits requires imaging techniques with high spatial resolution to facilitate neuron tracing and high ... -
Accelerating Discovery in Virtual Chemical Libraries
(2023-05-15)High-throughput virtual screening (HTVS) is an essential workflow in molecular discovery programs that aids researchers in prioritizing compounds for experimental testing within large libraries of molecules. The application ... -
Airborne Disease Transmission via Bioaerosols: Formation Mechanisms and the Influence of Viscoelasticity
(2013-03-18)Airborne disease transmission is a prominent problem facing an increasingly mobilized world. It involves small droplets (bioaerosols) containing pathogens which form in the lungs and are expelled to the environment, where ... -
Airway Dynamics and the Role of Zyxin
(2014-06-06)Morbidity and mortality attributable to asthma arise mainly from contraction of airway smooth muscle (ASM) and resulting bronchospasm. Bronchospasm that is induced in the laboratory is easily reversed by a spontaneous deep ... -
Allele-specific detection of single mRNA molecules in situ and the study of transcriptional regulation
(2014-10-21)We developed a method for fluorescence in situ identification of individual mRNA molecules, allowing quantitative and accurate measurement, in single cells, of allele-specific transcripts that differ by only a few nucleotides. ... -
Analyzing The Evolution and Diversification of Lepidoptera Using Multi-Spectral Images
(2023-06-01)Insects comprise an estimated 60% of all described species, and butterflies are among the best known of all insect taxa. The order Lepidoptera (butterflies and moths) contains approximately 160,000 species in 126 families. ... -
Angiotensin II Induced Cardiac Dysfunction on a Chip
(Public Library of Science, 2016)In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ... -
Applications of sequence coevolution in membrane protein biochemistry
(Elsevier BV, 2018-04)Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global statistical models of sequence coevolution, have enabled the ... -
Bayesian Inference Approaches for Particle Trajectory Analysis in Cell Biology
(2013-08-28)Despite the importance of single particle motion in biological systems, systematic inference approaches to analyze particle trajectories and evaluate competing motion models are lacking. An automated approach for robust ... -
Biology at single-molecule and single-cell level: chromosome organization, gene expression and beyond
(2014-06-06)Single molecules and single cells are the fundamental building blocks in biology. Facilitated by the advancement of technology, quantitative single-molecule and single-cell measurements provide a unique perspective toward ... -
Biometric Navigation with Ultrasound
(2013-04-16)We have designed and demonstrated a new class of medical navigation methods that use the fingerprint-like biometrically distinct ultrasound echo patterns produced by different locations in tissue. As an example of this new ... -
Biophysics of Kinetochore Microtubules in Human Mitotic Spindles
(2022-09-12)During eukaryotic cell division, chromosomes are linked to microtubules in the spindle by a macromolecular complex called the kinetochore. Regulation of these bound kinetochore micro- tubules is crucial to ensuring accurate ... -
Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers
(2013-10-15)Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ... -
Book Review: Gauge/Gravity Duality: Foundations and Applications
(Frontiers Media SA, 2018-08-31) -
Bringing bioelectricity to light: all-optical electrophysiology using microbial rhodopsins
(2014-10-21)My work has focused on the development and application of fluorescent voltage-sensitive proteins based on microbial rhodopsins. These probes led to the discovery of electrical activity in the bacterium Escherichia coli, ... -
Characterizing chemosensory responses in C. elegans with multi-neuronal imaging
(2021-07-12)How do animals use their sensory neurons to perceive their chemical environment? How does sensory information get transformed by downstream circuits? And ultimately, how do animals generate behavior in response to chemical ... -
Characterizing Regulatory Elements and Non-Coding Variants in the Human Genome
(2023-05-02)Regulatory elements and the non-coding variants within them govern the spatiotemporal expression of genes as part of coordinated sets of networks, mediated by the combinatorial binding of transcription factors. The mechanisms ... -
Chemical and Physical Determinants of Cell Migration
(2014-06-20)The phenomenon of directed cell motion in response to external directional cues has drawn significant interest for more than a century, with the first recorded observations of bacterial chemotaxis at the end of the 19th ... -
Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions
(Public Library of Science, 2014)The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are ... -
Computer Simulations of Protein Folding and Evolution
(2013-10-14)Computer simulations for investigating protein folding and evolution are presented. In chapter 1, an all-atom model with a knowledge-based potential is used to study the folding kinetics of Formin-Binding protein. We study ...