Now showing items 1-6 of 6

    • Dynamic Chromatin Organization during Foregut Development Mediated by the Organ Selector Gene PHA-4/FoxA 

      Fakhouri, Tala H. I.; Stevenson, Jeff; Chisholm, Andrew D.; Mango, Susan (Public Library of Science (PLoS), 2010)
      Central regulators of cell fate, or selector genes, establish the identity of cells by direct regulation of large cohorts of genes. In Caenorhabditis elegans, foregut (or pharynx) identity relies on the FoxA transcription ...
    • Genomic Variation and Its Impact on Gene Expression in Drosophila Melanogaster 

      Massouras, Andreas; Waszak, Sebastian M.; Albarca-Aguilera, Monica; Hens, Korneel; Holcombe, Wiebke; Ayroles, Julien; Dermitzakis, Emmanouil T.; Stone, Eric A.; Jensen, Jeffrey D.; Mackay, Trudy F. C.; Deplancke, Bart (Public Library of Science, 2012)
      Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model ...
    • MARIS: Method for Analyzing RNA following Intracellular Sorting 

      Hrvatin, Siniša; Deng, Francis; O'Donnell, Charles W.; Gifford, David K.; Melton, Douglas A. (Public Library of Science, 2014)
      Transcriptional profiling is a key technique in the study of cell biology that is limited by the availability of reagents to uniquely identify specific cell types and isolate high quality RNA from them. We report a Method ...
    • Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe 

      Dearborn, Richard E.; Dai, Yong; Reed, Brian; Karian, Tamar; Gray, Jessica; Kunes, Samuel M. (Public Library of Science, 2012)
      Receptors of the Eph family of tyrosine kinases and their Ephrin ligands are involved in developmental processes as diverse as angiogenesis, axon guidance and cell migration. However, our understanding of the Eph signaling ...
    • SiteOut: An Online Tool to Design Binding Site-Free DNA Sequences 

      Estrada, Javier; Ruiz-Herrero, Teresa; Scholes, Clarissa; Wunderlich, Zeba; DePace, Angela H. (Public Library of Science, 2016)
      DNA-binding proteins control many fundamental biological processes such as transcription, recombination and replication. A major goal is to decipher the role that DNA sequence plays in orchestrating the binding and activity ...
    • ZBED6 Modulates the Transcription of Myogenic Genes in Mouse Myoblast Cells 

      Jiang, Lin; Wallerman, Ola; Younis, Shady; Rubin, Carl-Johan; Gilbert, Elizabeth R.; Sundström, Elisabeth; Ghazal, Awaisa; Zhang, Xiaolan; Wang, Li; Mikkelsen, Tarjei S.; Andersson, Göran; Andersson, Leif (Public Library of Science, 2014)
      ZBED6 is a recently discovered transcription factor, unique to placental mammals, that has evolved from a domesticated DNA transposon. It acts as a repressor at the IGF2 locus. Here we show that ZBED6 acts as a transcriptional ...