Browsing Faculty of Arts and Sciences by Keyword "Differentiation"
Now showing items 1-4 of 4
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Characterization of transcription factor function during human gametogenesis via directed differentiation
(2022-06-06)It is estimated that one in ten people in the US struggle with infertility. Access to human germline cell types for study is limited, and little is known about the underlying genetic regulation of human gametogenesis. In ... -
A Synthetic Yeast Model for Differentiation and Division of Labor
(2014-06-06)To maintain high average fitness, populations must effect selection against the deleterious mutations that continuously arise de novo. Theoretical models of mutation-selection balance predict that the maximum tolerable ... -
Teleost Growth Factor Independence (Gfi) Genes Differentially Regulate Successive Waves of Hematopoiesis
(Elsevier BV, 2013)Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development ... -
ZNF335: A Novel Regulator of Stem Cell Proliferation and Cell Fate in the Cerebral Cortex
(2013-03-18)Though development of the cerebral cortex is of singular importance to human cognition, it remains very poorly understood. Microcephaly, or "small head," is a neurodevelopmental disorder causing significantly reduced ...