Browsing Faculty of Arts and Sciences by Keyword "Endocrinology"
Now showing items 1-6 of 6
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GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity
(Public Library of Science, 2012)Background: Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition ... -
Implementation and Outcomes of a Comprehensive Type 2 Diabetes Program in Rural Guatemala
(Public Library of Science, 2016)Background: The burden of chronic, non-communicable diseases such as diabetes is growing rapidly in low- and middle-income countries. Implementing management programs for diabetes and other chronic diseases for underserved ... -
Polygenic architecture of human body size and proportion
(2023-11-21)Over the last 15 years, genome-wide association studies (GWAS) have discovered thousands of genetic associations with human phenotypes. However, as most of these associations lie in non-coding regions and are typically ... -
Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming
(Public Library of Science, 2014)Type-1 diabetes (T1D) is an autoimmune disease in which insulin-secreting pancreatic beta cells are destroyed by the immune system. An emerging strategy to regenerate beta-cell mass is through transdifferentiation of ... -
Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy
(Public Library of Science, 2016)The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies ... -
Two of a Kind or a Full House? Reproductive Suppression and Alloparenting in Laboratory Mice
(Public Library of Science, 2016)Alloparenting, a behavior in which individuals other than the actual parents act in a parental role, is seen in many mammals, including house mice. In wild house mice, alloparental care is only seen when familiar sibling ...