Browsing Faculty of Arts and Sciences by Keyword "Histone Modification"

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    • Genomic Variation and Its Impact on Gene Expression in Drosophila Melanogaster 

      Massouras, Andreas; Waszak, Sebastian M.; Albarca-Aguilera, Monica; Hens, Korneel; Holcombe, Wiebke; Ayroles, Julien; Dermitzakis, Emmanouil T.; Stone, Eric A.; Jensen, Jeffrey D.; Mackay, Trudy F. C.; Deplancke, Bart (Public Library of Science, 2012)
      Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model ...

    • A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests 

      Schroeder, Frederick A.; Lewis, Michael C.; Fass, Daniel M.; Wagner, Florence F.; Zhang, Yan-Ling; Hennig, Krista M.; Gale, Jennifer; Zhao, Wen-Ning; Reis, Surya; Barker, Douglas D.; Berry-Scott, Erin; Kim, Sung Won; Clore, Elizabeth L.; Hooker, Jacob M.; Holson, Edward B.; Haggarty, Stephen J.; Petryshen, Tracey L. (Public Library of Science, 2013)
      Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary – albeit often ineffective – treatment ...