Browsing Faculty of Arts and Sciences by Keyword "Immunology"
Now showing items 1-20 of 134
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A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
(2021-01-21)Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine that orchestrates the mobilization and activation of the immune system in response to infection. Its release is typically regulated by inflammasomes, multiprotein ... -
AAV-associated toxicity caused by transgene expression in the retinal pigment epithelium
(2024-01-26)The field of AAV gene therapy has recently experienced multiple clinical successes, and AAV continues to be a relatively safe viral vector. Nevertheless, there is a long history of toxic side effects at higher doses, ... -
The ALS-Linked Gene TDP-43 Regulates \(IFN\beta\) Expression through a Novel Mechanism of 3' UTR-Mediated Promoter cis-Regulation
(2013-03-20)The TAR DNA-binding protein (TDP-43) is a heterogeneous nuclear ribonucleprotein that is involved in multiple stages of RNA processing. Mutations in the TDP-43 gene and mislocalization of TDP-43 protein have been implicated ... -
Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
(Public Library of Science, 2016)Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ... -
Antigen-specific immune modulation using an injectable biomaterial
(2014-06-06)The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific ... -
Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil
(Public Library of Science, 2016)Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ... -
Biomaterial scaffold-based vaccines sustain robust immune responses through the lymph nodes
(2022-05-05)Emergent vaccine therapies aim to engineer the multi-scale interactions that naturally occur within lymph nodes (LNs), from cellular behavior to tissue dynamics. Therapeutic cancer vaccines have demonstrated safety and ... -
CD4+ T cell responses to the intracellular pathogen Chlamydia trachomatis
(2024-01-05)Chlamydia trachomatis (C. trachomatis) is the most common cause of bacterial sexually transmitted infection (STI) in both men and women. Immunity to C. trachomatis involves many cell types, but CD4+ T cells play a crucial ... -
Cell Fate Determination in the Innate Immune System
(2021-09-08)Phagocytes of the innate immune system adopt cell fates that serve distinct purposes during homeostasis or inflammation. The innate immune system performs threat assessments by integrating pattern recognition receptor (PRR) ... -
Cellular and Biochemical Events in Toll-like Receptor Signaling
(2014-06-06)In multicellular organisms, communication between cells relies on transmitting information across membrane barriers. Different cell types interrogate particular aspects of their surrounding environment through protein ... -
Cellular and Genetic Dynamics of the Melanoma Microenvironment
(2023-04-26)The tumor microenvironment is comprised of a diverse assemblage of cells. These populations dynamically interact with one another in varied ways that modify the individual cells and shape the overall trajectory of the ... -
Characterization of impaired CD8+ T cell responses to Chlamydia trachomatis
(2013-10-15)Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Irregular screening to identify infected individuals and a lack of sterilizing immunity to C. trachomatis has ... -
Characterizing immune crosstalk in the precancerous tissue
(2023-11-21)Extensive work within the field of cancer immunology has successfully characterized the tumor immune microenvironment and its impact on patient responses to therapy. However, there has been substantially less work dedicated ... -
Characterizing the Infection-Induced Transcriptome of Nasonia vitripennis Reveals a Preponderance of Taxonomically-Restricted Immune Genes
(Public Library of Science, 2013)The innate immune system in insects consists of a conserved core signaling network and rapidly diversifying effector and recognition components, often containing a high proportion of taxonomically-restricted genes. In the ... -
Circadian Regulation of Regulatory T Cells in Visceral Adipose Tissue
(2021-09-07)Regulatory T cells (Tregs) in non-lymphoid tissues provide critical brakes on inflammation and control tissue homeostasis. While tissue Tregs are phenotypically diverse, they may adopt common mechanisms to optimize their ... -
Codon bias and tRNA adaptation in antibody production
(2023-05-09)To protect against infection, antibodies must be produced at high rates, imposing significant pressure on the translational machinery of the B cells which produce them. The extent to which codon composition and the tRNA ... -
Comparative Genome Analyses Reveal Distinct Structure in the Saltwater Crocodile MHC
(Public Library of Science, 2014)The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. The MHC is generally divided into subregions (classes ... -
Comparative Genomics of the Major Histocompatibility Complex in Amniotes
(2013-03-18)The major histocompatibility complex region (MHC) is a multi gene family present in all jawed vertebrates, with a fundamental role in vertebrate immunity. More than two decades of studies have resulted in the characterization ... -
Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model
(Public Library of Science, 2014)Peripheral nerve injury (PNI), a common injury in both the civilian and military arenas, is usually associated with high healthcare costs and with patients enduring slow recovery times, diminished quality of life, and ... -
Cooking shapes the structure and function of the gut microbiome
(Springer Science and Business Media LLC, 2019-09-30)Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics. Numerous microbiome studies have compared diets with divergent ingredients, but the everyday practice of ...