Browsing Faculty of Arts and Sciences by Keyword "Immunotherapy"
Now showing items 1-11 of 11
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Antigen-specific immune modulation using an injectable biomaterial
(2014-06-06)The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific ... -
Discovery of smoking-related biomarkers for advanced treatment in non-small cell lung cancer (NSCLC)
(2022-03-17)Lung cancer is one of the most diagnosed cancers and the leading cause of cancer death globally. Up to 60% of the non-small cell lung cancer lung (NSCLC) cancer patients are diagnosed with distant metastases with a poor ... -
Harnessing Calcium Signaling in Dendritic Cells - A Potential Approach to Modulate the Immune Response In Vivo for Immunotherapy
(2013-10-08)Over the past several decades, our understanding of the immune system has advanced considerably. With it, an appreciation for its role in a number of diseases, such as cancer and infection has significantly grown. While ... -
Immunotherapy in the Precision Medicine Era: Melanoma and Beyond
(Public Library of Science, 2016)In a Perspective, Mack Su and David Fisher discuss the development of immunotherapies for treatment of melanoma and other cancer types. -
Mechano-immuno-therapy for Skeletal Muscle Repair
(2022-09-12)Traumatic skeletal muscle injuries account for a significant fraction of all healthcare-related costs and compromise quality of life for thousands of patients each year. Severe muscle injuries involve damage that is beyond ... -
Myeloid cells in systemic immune reactions during cancer
(2022-01-14)The immune system plays diverse roles during cancer—it can be protective against tumor growth, yet it may also foster cancer progression in some settings. Anti-cancer immunotherapy can simultaneously trigger both productive ... -
Neutrophils for Cancer Immunotherapy
(2023-06-01)Neutrophils are the most abundant leukocytes in human blood circulation and are the first responders to the site of inflammation including tumors. Tumor-Associated Neutrophils (TANs) assume a pro-tumor phenotype in the ... -
Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies
(2023-05-02)Adoptive T cell therapy (ACT), including chimeric antigen receptor (CAR) T cell therapy, is a type of immunotherapy that typically uses a patient’s own T cells to treat tumors. While ACT has demonstrated tremendous success ... -
Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study
(S. Karger AG, 2012)Background: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition ... -
Polymer Micropatches as Cell Engagers for Cancer Immunotherapy
(2023-11-21)Adoptive transfer of immune cells has emerged as a potential therapeutic approach against various cancers. The effectiveness of cell-based therapies is limited by an inability to control the cell phenotype post in vivo ... -
Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer
(2022-06-06)Chimeric antigen receptor (CAR) T cell therapy has been highly successful in the treatment of B cell malignancies, with response rates ranging from 50 to 90% and many patients achieving durable complete responses. This ...