Browsing Faculty of Arts and Sciences by Keyword "Malaria"
Now showing items 1-15 of 15
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Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium Vivax
(Springer Science + Business Media, 2013)Antifolate antimalarials, such as pyrimethamine, have experienced a dramatic reduction in therapeutic efficacy as resistance has evolved in multiple malaria species. We present evidence from one such species, Plasmodium ... -
An integrated chemogenomic approach exploring and exploiting prolyl-tRNA synthetase as target for next-generation malaria and cancer therapies
(2022-11-23)Malaria is an infectious disease caused by Plasmodium parasites and remains one of the world’s most pressing public health challenges with nearly half of the world’s population at risk, causing over 200 million cases and ... -
Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal
(BioMed Central, 2013)Background: Malaria treatment efforts are hindered by the rapid emergence and spread of drug resistant parasites. Simple assays to monitor parasite drug response in direct patient samples (ex vivo) can detect drug resistance ... -
Comparing research investment to United Kingdom institutions and published outputs for tuberculosis, HIV and malaria: a systematic analysis across 1997–2013
(BioMed Central, 2015)Background: The “Unfinished Agenda” of infectious diseases is of great importance to policymakers and research funding agencies that require ongoing research evidence on their effective management. Journal publications ... -
Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease
(2013-08-28)Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the ... -
Ecological pressures affecting malaria transmission: sex, insecticides, and Wolbachia in Anopheles mosquitoes
(2021-09-08)Anopheles mosquitoes are the only vectors of malaria, a disease that kills over 400,000 people each year. In malaria-endemic regions, interventions aimed at the mosquito vectors through the use of insecticides have been ... -
Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
(BioMed Central, 2017)Background: As public health interventions drive parasite populations to elimination, genetic epidemiology models that incorporate population genomics can be powerful tools for evaluating the effectiveness of continued ... -
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal
(Public Library of Science, 2013)Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically ... -
Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance
(2013-10-18)Malaria is a preventable and treatable disease caused by infection with Plasmodium parasites. Complex socioeconomic and political factors limit access to vector control and antimalarial drugs, and an estimated 600,000 ... -
The Impact of Text Message Reminders on Adherence to Antimalarial Treatment in Northern Ghana: A Randomized Trial
(Public Library of Science, 2014)Background: Low rates of adherence to artemisinin-based combination therapy (ACT) regimens increase the risk of treatment failure and may lead to drug resistance, threatening the sustainability of current anti-malarial ... -
Integrative Antiparasitic & Erythrotoxic Characterization of a Red Blood Cell Host-Biased Compound Library
(2022-05-10)Malaria is a deadly mosquito-transmitted disease caused by Apicomplexan Plasmodium parasites that infect millions of people every year: In 2020 alone, 241 million people were infected by the parasites and ~627,000 people ... -
Modeling Behavioral and Biological Complexities of Malaria Control
(2022-03-17)Malaria, caused by a single-cell parasite and transmitted by blood-feeding mosquitoes, is one of the world's leading infectious diseases in terms of both morbidity and mortality. While the first two decades of the ... -
Molecular requirements for morphogenesis in Plasmodium falciparum, the human malaria parasite
(2021-03-05)Malaria, which is caused by Plasmodium parasites, remains a major cause of illness and death worldwide. P. falciparum, the parasite responsible for severe malaria, alters its shape dramatically during development to adapt ... -
Pre-clinical studies characterizing the evolutionary dynamics of resistance to novel antimalarials in Plasmodium falciparum
(2021-05-07)Malaria, caused by protozoan parasites of the genus Plasmodium, affects millions of people and is a leading cause of childhood mortality. Antimalarial treatments save lives and are an important cornerstone of the global ... -
Using search queries for malaria surveillance, Thailand
(BioMed Central, 2013)Background: Internet search query trends have been shown to correlate with incidence trends for select infectious diseases and countries. Herein, the first use of Google search queries for malaria surveillance is investigated. ...