Browsing Faculty of Arts and Sciences by Keyword "Zebrafish"

Now showing items 1-18 of 18

    • Bioelectric Signaling Regulates Size in Zebrafish Fins 

      Perathoner, Simon; Daane, Jacob M.; Henrion, Ulrike; Seebohm, Guiscard; Higdon, Charles W.; Johnson, Stephen L.; Nüsslein-Volhard, Christiane; Harris, Matthew P. (Public Library of Science, 2014)
      The scaling relationship between the size of an appendage or organ and that of the body as a whole is tightly regulated during animal development. If a structure grows at a different rate than the rest of the body, this ...

    • Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion 

      Dunn, Timothy W; Mu, Yu; Narayan, Sujatha; Randlett, Owen; Naumann, Eva A; Yang, Chao-Tsung; Schier, Alexander F; Freeman, Jeremy; Engert, Florian; Ahrens, Misha B (eLife Sciences Publications, Ltd, 2016)
      In the absence of salient sensory cues to guide behavior, animals must still execute sequences of motor actions in order to forage and explore. How such successive motor actions are coordinated to form global locomotion ...

    • Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio) 

      Uribe, Phillip M.; Mueller, Melissa; Gleichman, Julia S.; Kramer, Matthew; Wang, Qi; Sibrian-Vazquez, Martha; Strongin, Robert M.; Steyger, Peter S.; Cotanche, Douglas; Matsui, Jonathan I. (Public Library of Science, 2013)
      Inner ear sensory hair cells die following exposure to aminoglycoside antibiotics or chemotherapeutics like cisplatin, leading to permanent auditory and/or balance deficits in humans. Zebrafish (Danio rerio) are used to ...

    • DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish 

      Liu, Xiaohui; Jia, Xiaoe; Yuan, Hao; Ma, Ke; Chen, Yi; Jin, Yi; Deng, Min; Pan, Weijun; Chen, Saijuan; Chen, Zhu; de The, Hugues; Zon, Leonard I; Zhou, Yi; Zhou, Jun; Zhu, Jun (BioMed Central, 2015)
      Background: DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development ...

    • The effects of nicotine on cone and rod b-wave responses in larval zebrafish 

      Moyano, Miguel; Porteros, Ángel; Dowling, John E. (Cambridge University Press (CUP), 2013-06-28)
      Acetylcholine is present in and released from starburst amacrine cells in the inner plexiform layer (IPL), but its role in retinal function except, perhaps, in early development, is unclear. Nicotinic acetylcholine receptors ...

    • Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs 

      Gagnon, James A.; Valen, Eivind; Thyme, Summer B.; Huang, Peng; Ahkmetova, Laila; Pauli, Andrea; Montague, Tessa G.; Zimmerman, Steven; Richter, Constance; Schier, Alexander F. (Public Library of Science, 2014)
      The CRISPR/Cas9 system has been implemented in a variety of model organisms to mediate site-directed mutagenesis. A wide range of mutation rates has been reported, but at a limited number of genomic target sites. To uncover ...

    • FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution 

      Eames, B Frank; DeLaurier, April; Ullmann, Bonnie; Huycke, Tyler R; Nichols, James T; Dowd, John; McFadden, Marcie; Sasaki, Mark M; Kimmel, Charles B (BioMed Central, 2013)
      Background: The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution. ...

    • Interrogating the differential roles of Ezh1/2 in hematopoietic stem and progenitor cell formation from endothelial precursors 

      Soto, Rebecca Annette (2021-09-09)
      Understanding how hematopoietic stem and progenitor cells (HSPCs) are specified from endothelial precursors is essential to the goal of generating patient-specific HSPCs for therapeutic use. Coordinated action of cell ...

    • Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma 

      Tenente, Inês M; Hayes, Madeline N; Ignatius, Myron S; McCarthy, Karin; Yohe, Marielle; Sindiri, Sivasish; Gryder, Berkley; Oliveira, Mariana L; Ramakrishnan, Ashwin; Tang, Qin; Chen, Eleanor Y; Petur Nielsen, G; Khan, Javed; Langenau, David M (eLife Sciences Publications, Ltd, 2017)
      Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely ...

    • Non-classical amine recognition evolved in a large clade of olfactory receptors 

      Li, Qian; Tachie-Baffour, Yaw; Liu, Zhikai; Baldwin, Maude W; Kruse, Andrew C; Liberles, Stephen D (eLife Sciences Publications, Ltd, 2015)
      Biogenic amines are important signaling molecules, and the structural basis for their recognition by G Protein-Coupled Receptors (GPCRs) is well understood. Amines are also potent odors, with some activating olfactory trace ...

    • On the role of the stem cell niche in hematopoietic development 

      Wattrus, Samuel James (2023-01-06)
      Hematopoietic stem cells (HSCs) emerge from a population of specialized endothelial cells in the aorta during embryogenesis. These cells then migrate to a temporary niche where they reside and proliferate for the rest of ...

    • The Role of Estrogen Signaling in the Induction, Specification, and Proliferation of Hematopoietic Stem Cells 

      Carroll, Kelli Jane (2014-06-06)
      Hematopoietic Stem Cells (HSCs) are characterized by their ability to both self-renew and give rise to all lineages of the blood system. A recent chemical genetic screen identified 17β-estradiol (estrogen) as a novel ...

    • The Role of Nuclear Receptor Signaling in Vertebrate Liver Development 

      Garnaas, Maija Kristine (2014-06-06)
      Proper embryonic development requires precise genetic regulation of cell growth and differentiation. Organogenesis, the origin and formation of internal organs, must be exquisitely choreographed to ensure correct temporal ...

    • The Transcriptional Biographies of Embryonic Cells 

      Wang, Yiqun (2021-05-13)
      During metazoan development, a single totipotent cell is transformed into an organism comprised of numerous cell types with distinct structures, functions and transcriptional states. Therefore, two central questions in ...

    • Transcriptional Response and Immune Activation after Morphogen Signaling in Melanoma 

      Noonan, Haley (2022-06-06)
      TGFb and Wnt developmental signaling pathways are commonly dysregulated in cancer; this includes melanoma, the deadliest form of skin cancer. These pathways terminate in signaling transcription factors (TFs) binding to ...

    • Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish 

      Mosimann, Christian; Kaufman, Charles Kore; Li, Pulin; Pugach, Emily K.; Tamplin, Owen J.; Zon, Leonard Ira (The Company of Biologists, 2010)
      Molecular genetics approaches in zebrafish research are hampered by the lack of a ubiquitous transgene driver element that is active at all developmental stages. Here, we report the isolation and characterization of the ...

    • Vitamin D Receptor regulation of hepatic and organismal energy metabolism 

      Freeburg, Scott Hull (2023-06-01)
      Epidemiological and experimental studies have demonstrated a role for vitamin D and its effector Vitamin D Receptor (VDR) in the pathogenesis of metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and ...

    • Zebrafish Globin Switching Occurs in Two Developmental Stages and Is Controlled by the LCR 

      Ganis, Jared Jason; Hsia, Nelson; Trompouki, Eirini; de Jong, Jill L.O.; DiBiase, Anthony; Lambert, Janelle S.; Jia, Zhiying; Sabo, Peter J.; Weaver, Molly; Sandstrom, Richard; Stamatoyannopoulos, John A.; Zhou, Yi; Zon, Leonard Ira (Elsevier BV, 2012)
      Globin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based ...