Browsing Faculty of Arts and Sciences by Keyword "antibiotic resistance"
Now showing items 1-7 of 7
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Adaptive Landscapes and Protein Evolution
(National Academy of Sciences, 2010)The principles governing protein evolution under strong selection are important because of the recent history of evolved resistance to insecticides, antibiotics, and vaccines. One experimental approach focuses on studies ... -
Combination Antibiotic-Focused Machine Learning Models for Integration into Experimental Workflows
(2022-06-02)Antibiotic resistance is a growing crisis with far-reaching impacts on public and global health [1][2]. With antibiotic resistance impeding the efficacy of antibiotics and the discovery of new antibiotics slowing [2], ... -
Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope
(2022-05-11)Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ... -
Exploring Bystander Selection for Antibiotic Resistance
(2021-03-05)Antibiotic consumption exerts selection for antibiotic resistance. Due to the wide spectrum of activity of many antibiotics, a single antibiotic use may impose selective pressures on a range of bacterial species, including ... -
Isolated cell behavior drives the evolution of antibiotic resistance
(John Wiley & Sons, Ltd, 2015)Bacterial antibiotic resistance is typically quantified by the minimum inhibitory concentration (MIC), which is defined as the minimal concentration of antibiotic that inhibits bacterial growth starting from a standard ... -
Reconstitution of the PBP2-PBP2a Complex from Methicillin-Resistant Staphylococcus aureus
(2021-11-16)β-lactams are commonly-used antibiotics that target penicillin-binding proteins (PBPs), the enzymes which build the bacterial cell wall. In methicillin-resistant Staphylococcus aureus (MRSA), resistance to these drugs is ... -
Temporal Constraints on the Incorporation of Regulatory Mutants in Evolutionary Pathways
(Oxford University Press, 2009)Understanding the molecular details of the sequence of events in multistep evolutionary pathways can reveal the extent to which natural selection exploits regulatory mutations affecting expression, amino acid replacements ...