Browsing Faculty of Arts and Sciences by Keyword "cancer"
Now showing items 1-20 of 41
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The Axis of Progression of Disease
(Libertas Academica, 2014)Starting with genetic or environmental perturbations, disease progression can involve a linear sequence of changes within individual cells. More often, however, a labyrinth of branching consequences emanates from the initial ... -
Cancer Genome Characterization with SNP Array and Whole-Exome Sequencing Analysis
(2013-02-25)Cancer, the uncontrolled growth of morphologically and genetically abnormal cells in the body, is a major worldwide public health problem and there is a great need for novel insights into this disease. The majority of ... -
Characterization of the functions and therapeutic potential of deubiquitinating enzymes in oncology
(2021-09-02)DUBs are dysregulated in cancer and other diseases, but there is much that is unknown about the specific substrates and pathways that individual DUBs regulate and their clinical utility remains incompletely explored. In ... -
Combination Therapy: Histone Deacetylase Inhibitors and Platinum-Based Chemotherapeutics for Cancer
(Elsevier BV, 2013)One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of ... -
A Correlated-Polaron Electronic Propagator: Open Electronic Dynamics beyond the Born-Oppenheimer Approximation
(American Institute of Physics, 2012)In this work, we develop an approach to treat correlated many-electron dynamics, dressed by the presence of a finite-temperature harmonic bath. Our theory combines a small polaron transformation with the second-order ... -
Deep Sequencing and Functional Analyses Identify a Role of Fusobacterium Species in Colorectal Tumorigenesis
(2013-09-30)The tumor microenvironment is a complex community consisting of neoplastic cells, surrounding stromal cells, a broad array of immune cells, and a microbiota. By sheer numbers, the microbiota has its greatest manifestation ... -
The effect of one additional driver mutation on tumor progression
(Blackwell Publishing Ltd, 2013)Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting ... -
Engineering Protease Activity Sensors and Machine Learning Methods to Detect and Characterize Disease
(2021-05-11)Precision medicine promises the ability to intelligently tailor clinical interventions to individual patient needs. Personalizing clinical management will necessitate access to high quality, accurate, and functional ... -
Environmental Barriers to T Cell Metabolism and Function
(2022-03-17)Immunometabolism describes the interface between immune cell function and metabolism. This interplay is governed by both cell-intrinsic metabolic programs that shape immune cell function, as well as environmental metabolites ... -
Evolutionary dynamics of cancer in response to targeted combination therapy
(eLife Sciences Publications, Ltd, 2013)In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. ... -
Explorations in cancer genomics and tumor immunology through analysis of next-generation sequencing data
(2022-03-17)Cancer is an evolutionary disease. From the time we are a fertilized egg, our cells are subject to processes that can alter DNA sequence and epigenetics leading to random changes in cell fitness. Certain phenotypes can ... -
Genome-wide Integrative Analysis of Transcription Factor Occupancy and Gene Regulation in Models of Human Cancer and Cellular Differentiation
(2012-11-19)Few transcription factors (TFs) have been studied in the context of an integrative analysis incorporating genomic datasets from diverse genome regulatory mechanisms. Such an analysis allows the testing of specific regulatory ... -
Health Communication in the Digital Age: Young Adult Experiences in Sexual Health, Body Image, and Cancer
(2021-03-05)Young adulthood is a developmental stage traditionally characterized by developing autonomy from parents, transitioning from school to work, forming one’s own family, and other similar milestones that shape the trajectory ... -
Identification and Analysis of a New Tumor and Metastasis Suppressor Gene, RASAL2
(2013-10-08)RAS is one of the most commonly mutated genes in human cancer; its aberrant activation drives tumor cell proliferation and survival. However, RAS mutations are rare in some cancers, including breast cancer, even though ... -
Mathematical Models of Cancer
(2013-02-22)Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major ... -
Metabolic Heterogeneity in Molecular Subsets of Diffuse Large B-cell Lymphoma
(2014-10-21)Cells adapt their metabolism to satisfy changing bioenergetic and biosynthetic needs. Investigation of metabolic reprogramming in cancer has provided insight into the metabolic control of proliferation and survival. While ... -
MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model
(2013-03-08)Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, ... -
Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases
(2013-02-11)Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional ... -
Multi-omics interrogation of metabolic stress in cancer
(2024-03-12)Cancer is associated with alterations to many pathways and cellular processes, including activation of pro-growth cell signaling pathways, resistance to cell death, activation of metastasis, and evasion of the immune system. ... -
Neutrophil heterogeneity in cancer
(2023-01-20)Neutrophils are abundant in a wide range of cancer types and are classically considered to be tumor-promoting cells associated with poor clinical outcomes. However, emerging evidence suggests that tumor-associated neutrophils ...