Browsing Faculty of Arts and Sciences by Keyword "conformational change"
Now showing items 1-2 of 2
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Phosphatidylinositol-4,5-Biphosphate-Dependent Rearrangement of TRPV4 Cytosolic Tails Enables Channel Activation by Physiological Stimuli
(National Academy of Sciences, 2013)Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-biphosphate (PIP\(_2\)), although the structural rearrangements occurring on PIP\(_2\) binding are currently far from clear. Here ... -
Sequential conformational rearrangements in flavivirus membrane fusion
(eLife Sciences Publications, Ltd, 2014)The West Nile Virus (WNV) envelope protein, E, promotes membrane fusion during viral cell entry by undergoing a low-pH triggered conformational reorganization. We have examined the mechanism of WNV fusion and sought evidence ...