Browsing Faculty of Arts and Sciences by Keyword "disease models"
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A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs
(Public Library of Science, 2011)Hereditary periodic fever syndromes are characterized by recurrent episodes of fever and inflammation with no known pathogenic or autoimmune cause. In humans, several genes have been implicated in this group of diseases, ... -
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans
(Public Library of Science, 2006)The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to ... -
Using Expression and Genotype to Predict Drug Response in Yeast
(Public Library of Science, 2009)Personalized, or genomic, medicine entails tailoring pharmacological therapies according to individual genetic variation at genomic loci encoding proteins in drug-response pathways. It has been previously shown that ...