Browsing Faculty of Arts and Sciences by Keyword "dopamine"

Now showing items 1-14 of 14

    • Basal Ganglia Dynamics During Spontaneous Behavior 

      Gillis, Winthrop (2023-12-19)
      Animal behavior is composed of modular actions that are concatenated into sequences by the brain. The dorsolateral striatum (DLS), an integral component of the input nucleus to the basal ganglia, has been implicated in ...

    • Dissecting the Composition of Striatal Dopamine Release Machinery 

      Kershberg, Lauren (2021-11-16)
      There are two general modes of neurotransmission. In synaptic transmission, neurotransmitter-filled vesicles are rapidly released, and the signal is sensed by the target cell in a spatially and temporally precise manner. ...

    • Dopamine D1 signaling organizes network dynamics underlying working memory 

      Roffman, Joshua L.; Tanner, Alexandra S.; Eryilmaz, Hamdi; Rodriguez-Thompson, Anais; Silverstein, Noah J.; Ho, New Fei; Nitenson, Adam Z.; Chonde, Daniel B.; Greve, Douglas N.; Abi-Dargham, Anissa; Buckner, Randy L.; Manoach, Dara S.; Rosen, Bruce R.; Hooker, Jacob M.; Catana, Ciprian (American Association for the Advancement of Science, 2016)
      Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ...

    • Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass 

      Menegas, William; Bergan, Joseph F; Ogawa, Sachie K; Isogai, Yoh; Umadevi Venkataraju, Kannan; Osten, Pavel; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2015)
      Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ...

    • Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass 

      Menegas, William; Bergan, Joseph F; Ogawa, Sachie K; Isogai, Yoh; Umadevi Venkataraju, Kannan; Osten, Pavel; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2015)
      Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ...

    • Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans 

      Omura, Daniel T.; Clark, Damon A.; Samuel, Aravinthan DT; Horvitz, H. Robert (Public Library of Science, 2012)
      Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight ...

    • Dynamic dopaminergic activity controls the timing of self-timed movement. 

      Hamilos, Allison Elizabeth (2021-05-14)
      What makes us move? Human movement disorders like Parkinson’s disease have long suggested a vital role for dopamine in movement initiation, but there exists surprisingly little evidence connecting endogenous dopaminergic ...

    • Euthymic Patients with Bipolar Disorder Show Decreased Reward Learning in a Probabilistic Reward Task 

      Pizzagalli, Diego A; Goetz, Elena; Ostacher, Michael; Iosifescu, Dan V.; Perlis, Roy H. (Elsevier, 2008)
      Background: Bipolar disorder (BPD) features cycling mood states ranging from depression to mania with intermittent phases of euthymia. Bipolar disorder subjects often show excessive goal-directed and pleasure-seeking ...

    • Increased Perceived Stress is Associated with Blunted Hedonic Capacity: Potential Implications for Depression Research 

      Pizzagalli, Diego A; Bogdan, Ryan; Ratner, Kyle G.; Jahn, Allison L. (Elsevier Science, 2007)
      Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity, in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards ...

    • Midbrain dopamine neurons signal aversion in a reward-context-dependent manner 

      Matsumoto, Hideyuki; Tian, Ju; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2016)
      Dopamine is thought to regulate learning from appetitive and aversive events. Here we examined how optogenetically-identified dopamine neurons in the lateral ventral tegmental area of mice respond to aversive events in ...

    • Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice 

      Menegas, William; Babayan, Benedicte M; Uchida, Naoshige; Watabe-Uchida, Mitsuko (eLife Sciences Publications, Ltd, 2017)
      Dopamine neurons are thought to encode novelty in addition to reward prediction error (the discrepancy between actual and predicted values). In this study, we compared dopamine activity across the striatum using fiber ...

    • A Receptor-Based Model for Dopamine-Induced fMRI Signal 

      Mandeville, Joseph B.; Sander, Christin Y.M.; Jenkins, Bruce Gorton; Hooker, Jacob M; Catana, Ciprian; Vanduffel, Wim J.M.; Alpert, Nathaniel Moritz; Rosen, Bruce; Normandin, Marc D (Elsevier BV, 2013)
      This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in basal ganglia. The model is formulated as a summation of ...

    • Single Dose of a Dopamine Agonist Impairs Reinforcement Learning in Humans: Behavioral Evidence from a Laboratory-based Measure of Reward Responsiveness 

      Pizzagalli, Diego A; Evins, Anne; Schetter, Erika Cowman; Frank, Michael J.; Pajtas, Petra E.; Santesso, Diane L.; Culhane, Melissa (Springer Verlag, 2008)
      Rationale. The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related ...

    • Striatal dopamine structures spontaneous behavior across multiple timescales 

      Jay, Maya (2024-01-03)
      Animals maneuver through the world by building elaborated, flexible sequences out of shorter, stereotyped actions. In the mammalian brain, monosynaptic and multi-synaptic circuits in cortico-striatal loops are thought to ...