Browsing Faculty of Arts and Sciences by Keyword "drug discovery"
Now showing items 1-8 of 8
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Accelerating Discovery in Virtual Chemical Libraries
(2023-05-15)High-throughput virtual screening (HTVS) is an essential workflow in molecular discovery programs that aids researchers in prioritizing compounds for experimental testing within large libraries of molecules. The application ... -
Complementary Metal-Oxide-Semiconductor (CMOS) Bio-electronic Interface for Cell-based Phenotypic Drug Screening
(2021-07-12)Microelectrode Array (MEA) has been widely researched and with some commercial usage in measuring electrical properties and behavior of cardiac and neuronal networks, thanks to its low cost and parallelism compared to ... -
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
(Public Library of Science, 2008)Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical ... -
Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope
(2022-05-11)Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ... -
Empirical Bayes Analysis of Quantitative Proteomics Experiments
(Public Library of Science, 2009)Background: Advances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe ... -
Methods for the Identification of Ligand-Target Pairs from Combined Libraries of Targes and Ligands
(2014-06-06)Advances in genome and proteome research have led to a dramatic increase in the number of macromolecular targets of interest to the life sciences. A solution-phase method to simultaneously reveal all ligand-target binding ... -
Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate
(Public Library of Science, 2010)The mechanism of membrane fusion by “class II” viral fusion proteins follows a pathway that involves large-scale domain rearrangements of the envelope glycoprotein (E) and a transition from dimers to trimers. The rearrangement ... -
Understanding responses to chemical and environmental perturbations in blood stage Babesia parasites
(2022-05-05)Babesiosis is a disease caused by apicomplexan parasites related to the malaria parasite Plasmodium. Like Plasmodium, Babesia infects red blood cells (RBCs) in the host animal. Babesia is one of the most widespread blood ...