Browsing Faculty of Arts and Sciences by Keyword "gene regulation"
Now showing items 1-13 of 13
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Assessing modularity of developmental enhancers in Drosophila melanogaster
(2014-10-22)Gene expression is critical for animal development as cells divide and differentiate into multiple cell types. Cell-type specific gene expression is controlled by enhancers, DNA sequences that can direct expression of a ... -
Decoding Regulatory T Cell Transcription Factor Networks: From Identity to Diversity
(2023-11-21)Foxp3+CD4+ regulatory T cells (Tregs) are dominant controllers of immunological and organismal homeostasis. Tregs play diverse functional roles in lymphoid tissues, where they can adopt specialized phenotypes in response ... -
Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans
(Public Library of Science, 2012)Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight ... -
Elucidating the virulence control network in Francisella tularensis
(2014-06-06)The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia and a model intracellular pathogen. It is also considered a potential bioweapon, as F. tularensis is highly infectious and has the ... -
Engineered DNA-Binding Proteins for Targeted Genome Editing and Gene Regulation
(2013-10-08)Engineered DNA-binding proteins enable targeted manipulation of the genome. Zinc fingers are the most well characterized DNA-binding domain and for many years research has focused on understanding and manipulating the ... -
Gene-Drug Interactions and the Evolution of Antibiotic Resistance
(2013-03-18)The evolution of antibiotic resistance is shaped by interactions between genes, the chemical environment, and an antibiotic's mechanism of action. This thesis explores these interactions with experiments, theory, and ... -
Integrative analysis of large-scale single-cell genomics data in immune-mediated diseases
(2023-05-02)Recent advances in single-cell RNA sequencing have enabled the fine-grained characterization of heterogeneous cell types and states. However, integrating cells and effectively aligning shared cell states from disparate ... -
Lookahead and Piloting Strategies for Variable Selection
(International Chinese Statistical Association, 2007)The traditional variable selection problem has attracted renewed atten- tion from statistical researchers due to the recent advances in data collection, es- pecially in fields such as bioinformatics and marketing. In this ... -
Phenotypes and genetic mechanisms of C. elegans enhanced RNAi
(2013-10-08)RNA interference (RNAi) potently and specifically induces gene knockdown, and its potential for reverse genetics in Caenorhabditis elegans is enormous. However, even in these nematodes, RNAi can be induced more effectively ... -
Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
(BioMed Central, 2013)Background: The p53 transcription factor is located at the core of a complex wiring of signaling pathways that are critical for the preservation of cellular homeostasis. Only recently it has become clear that p53 regulates ... -
Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression
(Wiley-Blackwell, 2013)Numerous transcription factors (TFs) encode information about upstream signals in the dynamics of their activation, but how downstream genes decode these dynamics remains poorly understood. Using microfluidics to control ... -
Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe
(Public Library of Science, 2012)Receptors of the Eph family of tyrosine kinases and their Ephrin ligands are involved in developmental processes as diverse as angiogenesis, axon guidance and cell migration. However, our understanding of the Eph signaling ... -
The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast
(Oxford University Press, 2016)Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regulatory logic that remain poorly understood. We surveyed the yeast genome for tandem gene pairs oriented tail-to-head at ...