Browsing Faculty of Arts and Sciences by Keyword "high-throughput screening"
Now showing items 1-7 of 7
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Complementary Metal-Oxide-Semiconductor (CMOS) Bio-electronic Interface for Cell-based Phenotypic Drug Screening
(2021-07-12)Microelectrode Array (MEA) has been widely researched and with some commercial usage in measuring electrical properties and behavior of cardiac and neuronal networks, thanks to its low cost and parallelism compared to ... -
Discovery and Development of Novel Deubiquitinase Inhibitors via Parallel High-Throughput Screening
(2022-11-23)Ubiquitination is a critical post-translational modification in cell biology which results in a myriad of functional outcomes including proteasomal degradation of substrate proteins. The regulation of protein homeostasis ... -
Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope
(2022-05-11)Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ... -
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria
(AmericanChemical Society, 2011)Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis ... -
Genetic and Functional Studies of Non-Coding Variants in Human Disease
(2013-03-08)Genome-wide association studies (GWAS) of common diseases have identified hundreds of genomic regions harboring disease-associated variants. Translating these findings into an improved understanding of human disease requires ... -
High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling
(American Chemical Society, 2015)Cryptococcus neoformans is one of the most important human fungal pathogens; however, no new therapies have been developed in over 50 years. Fungicidal activity is crucially important for an effective anticryptococal agent ... -
Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis
(2013-01-02)Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ...