Browsing Faculty of Arts and Sciences by Keyword "immunotherapy"
Now showing items 1-4 of 4
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Explorations in cancer genomics and tumor immunology through analysis of next-generation sequencing data
(2022-03-17)Cancer is an evolutionary disease. From the time we are a fertilized egg, our cells are subject to processes that can alter DNA sequence and epigenetics leading to random changes in cell fitness. Certain phenotypes can ... -
Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
(2015)Materials implanted in the body to program host immune cells are a promising alternative to transplantation of ex vivo–manipulated cells to direct an immune response, but required a surgical procedure. Here we demonstrate ... -
MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model
(2013-03-08)Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, ... -
Relationship of vaccine efficacy to the kinetics of DC and T-cell responses induced by PLG-based cancer vaccines
(Landes Bioscience, 2011)Cancer vaccines are typically formulated for bolus injection and often produce short-lived immunostimulation resulting in poor temporal control over immune cell activation and weak oncolytic activity. One means of overcoming ...