Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection

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Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection

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Title: Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection
Author: Nandi, Bisweswar; Behar, Samuel M

Note: Order does not necessarily reflect citation order of authors.

Citation: Nandi, Bisweswar, and Samuel M. Behar. 2011. Regulation of neutrophils by interferon-\(\gamma\) limits lung inflammation during tuberculosis infection. The Journal of Experimental Medicine 208(11): 2251-2262.
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Abstract: Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) \(\gamma\) is crucial for activating macrophages and also regulates tissue inflammation. We dissociate these two functions and show that IFN-\(\gamma^{−/−}\) memory CD4\(^+\) T cells retain their antimicrobial activity but are unable to suppress inflammation. IFN-\(\gamma\) inhibits CD4\(^+\) T cell production of IL-17, which regulates neutrophil recruitment. In addition, IFN-\(\gamma\) directly inhibits pathogenic neutrophil accumulation in the infected lung and impairs neutrophil survival. Regulation of neutrophils is important because their accumulation is detrimental to the host. We suggest that neutrophilia during tuberculosis indicates failed Th1 immunity or loss of IFN-\(\gamma\) responsiveness. These results establish an important antiinflammatory role for IFN-\(\gamma\) in host protection against tuberculosis.
Published Version: doi:10.1084/jem.20110919
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201199/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10018996

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