Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link?
| Title: | Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link? |
| Author: |
Costenbader, Karen Harte; Karlson, Elizabeth Wood
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Costenbader, Karen H., and Elizabeth W. Karlson. 2006. Epstein–Barr virus and rheumatoid arthritis: Is there a link? Arthritis Research & Therapy 8(1): 204. |
| Full Text & Related Files: |
1526553.pdf (78.65Kb; PDF) 
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| Abstract: | Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein–Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein–Barr virus and rheumatoid arthritis is reviewed. |
| Published Version: | doi://10.1186/ar1893 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526553/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10021571 |
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