Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link?

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Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link?

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Title: Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link?
Author: Costenbader, Karen Harte; Karlson, Elizabeth Wood

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Citation: Costenbader, Karen H., and Elizabeth W. Karlson. 2006. Epstein–Barr virus and rheumatoid arthritis: Is there a link? Arthritis Research & Therapy 8(1): 204.
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Abstract: Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein–Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein–Barr virus and rheumatoid arthritis is reviewed.
Published Version: doi://10.1186/ar1893
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526553/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10021571

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