Familial Breast Cancer and the hCHK2 1100delC Mutation: Assessing Cancer Risk

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Familial Breast Cancer and the hCHK2 1100delC Mutation: Assessing Cancer Risk

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Title: Familial Breast Cancer and the hCHK2 1100delC Mutation: Assessing Cancer Risk
Author: Varley, Jenny; Haber, Daniel Arie

Note: Order does not necessarily reflect citation order of authors.

Citation: Varley, Jenny, and Daniel A. Haber. 2003. Familial breast cancer and the hCHK2 1100delC mutation: Assessing cancer risk. Breast Cancer Research 5(3): 123-125.
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Abstract: Germline mutations in the human checkpoint gene, hCHK2, were first identified in 1999 in cases of Li–Fraumeni syndrome. Recent studies have demonstrated that the hCHK2 1100delC mutation acts as a low-penetrance tumour suppressor gene in familial breast cancer not associated with mutations in BRCA1 or BRCA2. The present article describes the published studies on hCHK2 1100delC and addresses some of the key questions raised.
Published Version: doi: 10.1186/bcr582
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164998/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10024365

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