Gene Expression-Based Screening for Inhibitors of PDGFR Signaling

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Gene Expression-Based Screening for Inhibitors of PDGFR Signaling

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Title: Gene Expression-Based Screening for Inhibitors of PDGFR Signaling
Author: Antipova, Alena A.; Stockwell, Brent R.; Golub, Todd R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Antipova, Alena A., Brent R. Stockwell, and Todd R. Golub. 2008. Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biology 9(3): R47.
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Abstract: Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest.
Published Version: doi://10.1186/gb-2008-9-3-r47
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397499/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10024401

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