dc.contributor.author | Antipova, Alena A. | |
dc.contributor.author | Stockwell, Brent R. | |
dc.contributor.author | Golub, Todd R. | |
dc.date.accessioned | 2012-12-11T16:44:03Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Antipova, Alena A., Brent R. Stockwell, and Todd R. Golub. 2008. Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biology 9(3): R47. | en_US |
dc.identifier.issn | 1465-6906 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10024401 | |
dc.description.abstract | Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isversionof | doi://10.1186/gb-2008-9-3-r47 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397499/pdf/ | en_US |
dash.license | LAA | |
dc.subject | chronic myelomonocytic leukemia | en_US |
dc.subject | colony-stimulating factor | en_US |
dc.subject | aurintricarboxylic acid | en_US |
dc.subject | growth factor | en_US |
dc.subject | potent inhibitor | en_US |
dc.subject | receptor | en_US |
dc.subject | activation | en_US |
dc.subject | protein | en_US |
dc.subject | mechanism | en_US |
dc.title | Gene Expression-Based Screening for Inhibitors of PDGFR Signaling | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Genome Biology | en_US |
dash.depositing.author | Golub, Todd R. | |
dc.date.available | 2012-12-11T16:44:03Z | |
dash.affiliation.other | HMS^Pediatrics-Children's Hospital | en_US |
dc.identifier.doi | 10.1186/gb-2008-9-3-r47 | * |
dash.contributor.affiliated | Golub, Todd | |