dc.contributor.author | Roche-Labarbe, Nadege | |
dc.contributor.author | Fenoglio, Angela Joyce | |
dc.contributor.author | Aggarwal, Alpna | |
dc.contributor.author | Dehaes, Mathieu | |
dc.contributor.author | Carp, Stefan A. | |
dc.contributor.author | Franceschini, Maria A. | |
dc.contributor.author | Grant, Patricia Ellen | |
dc.date.accessioned | 2012-12-11T18:50:37Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Roche-Labarbe, Nadège, Angela Fenoglio, Alpna Aggarwal, Mathieu Dehaes, Stefan A. Carp, Maria Angela Franceschini, and Patricia Ellen Grant. 2012. Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain. Journal of Cerebral Blood Flow & Metabolism 32:481-488. | en_US |
dc.identifier.issn | 0271-678X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10026708 | |
dc.description.abstract | Little is known about cerebral blood flow, cerebral blood volume (CBV), oxygenation, and oxygen consumption in the premature newborn brain. We combined quantitative frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation \((SO_2\)) and CBV with diffusion correlation spectroscopy measures of cerebral blood flow index \((BF_{ix}\)) to determine the relationship between these measures, gestational age at birth (GA), and chronological age. We followed 56 neonates of various GA once a week during their hospital stay. We provide absolute values of \(SO_2\) and CBV, relative values of \(BF_{ix}\), and relative cerebral metabolic rate of oxygen (\(rCMRO_2\)) as a function of postmenstrual age (PMA) and chronological age for four GA groups. \(SO_2\) correlates with chronological age (r=−0.54, P value \(\leq\)0.001) but not with PMA (r=−0.07), whereas \(BF_{ix}\) and \(rCMRO_2\) correlate better with PMA (r=0.37 and 0.43, respectively, P value \(\leq\)0.001). Relative \(CMRO_2\) during the first month of life is lower when GA is lower. Blood flow index and \(rCMRO_2\) are more accurate biomarkers of the brain development than \(SO_2\) in the premature newborns. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | doi:10.1038/jcbfm.2011.145 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293111/pdf/ | en_US |
dash.license | LAA | |
dc.title | Near-infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Journal of Cerebral Blood Flow & Metabolism | en_US |
dash.depositing.author | Franceschini, Maria A. | |
dc.date.available | 2012-12-11T18:50:37Z | |
dc.identifier.doi | 10.1038/jcbfm.2011.145 | * |
dash.contributor.affiliated | Carp, Stefan | |
dash.contributor.affiliated | Roche-Labarbe, Nadege | |
dash.contributor.affiliated | Fenoglio, Angela Joyce | |
dash.contributor.affiliated | Dehaes, Mathieu | |
dash.contributor.affiliated | Franceschini, Maria | |