A Protective Role for BRCA2 at Stalled Replication Forks

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A Protective Role for BRCA2 at Stalled Replication Forks

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Title: A Protective Role for BRCA2 at Stalled Replication Forks
Author: Chandramouly, Gurushankar; Willis, Nicholas; Scully, Ralph

Note: Order does not necessarily reflect citation order of authors.

Citation: Chandramouly, Gurushankar, Nicholas A. Willis, and Ralph Scully. 2011. A protective role for BRCA2 at stalled replication forks. Breast Cancer Research 13:314.
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Abstract: The hereditary breast and ovarian cancer predisposition genes BRCA1 and BRCA2 account for the lion’s share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective homologous recombination (HR) and triggers genomic instability, accelerating breast tumorigenesis. A longstanding hypothesis proposes that BRCA1 and BRCA2 mediate HR following attempted replication across damaged DNA, ensuring error-free processing of the stalled replication fork. A recent paper describes a new replication fork protective function of BRCA2, which appears to collaborate with its HR function to suppress genomic instability.
Published Version: doi:10.1186/bcr2918
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10026709

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