MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes
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Author
Bastiani, Michele
Hill, Michelle M.
Nixon, Susan J.
Lo, Harriet P.
Abankwa, Daniel
Luetterforst, Robert
Fernandez-Rojo, Manuel
Breen, Michael R.
Vinten, Jorgen
Walser, Piers J.
North, Kathryn N.
Hancock, John F.
Pilch, Paul F.
Parton, Robert G.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1083/jcb.200903053Metadata
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Bastiani, Michele, Libin Liu, Michelle M. Hill, Mark P. Jedrychowski, Susan J. Nixon, Harriet P. Lo, Daniel Abankwa, et al. 2009. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. Journal of Cell Biology 185(7): 1259-1273.Abstract
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712963/pdf/Terms of Use
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