\(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo
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Author
Schrank, Benjamin R.
Benz, Eric G.
Moulia, Thomas W.
Rickenbacher, Gregory T.
Gomez, Alexis C.
Levites, Yona
Edwards, Sarah R.
Golde, Todd E.
Barnea, Gilad
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms2013Metadata
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Cao, Luxiang, Benjamin R. Schrank, Steven Rodriguez, Eric G. Benz, Thomas W. Moulia, Gregory T. Rickenbacher, Alexis C. Gomez, et al. 2012. \(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature Communications 3(8): 1009.Abstract
The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. Here we demonstrate that the connectivity of the peripheral olfactory neural circuit is perturbed in mice overexpressing human APPsw (Swedish mutation) before the onset of plaques. Expression of human APPsw exclusively in olfactory sensory neurons also perturbs connectivity with associated reductions in odour-evoked gene expression and olfactory acuity. By contrast, olfactory sensory neuron axons project correctly in mice overexpressing wild-type human amyloid precursor protein throughout the brain and in mice overexpressing M671V human APP, a missense mutation that reduces amyloid beta production, exclusively in olfactory sensory neurons. Furthermore, expression of Aβ40 or Aβ42 solely in the olfactory epithelium disrupts the olfactory sensory neuron axon targeting. Our data indicate that altering the structural connectivity and function of highly plastic neural circuits is one of the pleiotropic actions of soluble human amyloid beta.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529477/pdf/Terms of Use
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