Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development
View/ Open
Author
Teng, Ian
Huo, Randi
Rosenfeld, Michael G
Olson, Lorin E
Li, Xiaokun
Li, Xue
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1002/dvdy.23755Metadata
Show full item recordCitation
Sun, Ye, Ian Teng, Randi Huo, Michael G. Rosenfeld, Lorin E. Olson, Xiaokun Li, and Xue Li. 2012. Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development. Developmental Dynamics 241(4): 663-674.Abstract
Background: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell–cell communication pathways in metazoa. In this study, we report an unexpected stage- and tissue-specific function of β-catenin during mammalian jaw development. Results: Using a unique mouse genetic tool, we have discovered that epithelial β-catenin is essential for lower jaw formation, while attenuation of β-catenin is required for proper upper jaw development. Changes in β-catenin in vivo alter major epithelial Fgf8, Bmp4, Shh, and Edn1 signals, resulting in partial transcriptional reprogramming of the neural crest-derived mesenchyme, the primary source of jawbones. Conclusions: The Wnt/β-catenin signal coordinates expression of multiple epithelial signals and has stage-specific asymmetric functions during mammalian upper and lower jaw development. In addition, these findings suggest that evolutionary changes of the canonical Wnt/β-catenin signaling pathway may lead to innovation of jaws.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308359/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10628434
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)