Characterization of plasma thiol redox potential in a common marmoset model of aging☆
View/ Open
Author
Roede, James R.
Uppal, Karan
Liang, Yongliang
Promislow, Daniel E.L.
Jones, Dean P.
Published Version
https://doi.org/10.1016/j.redox.2013.06.003Metadata
Show full item recordCitation
Roede, James R., Karan Uppal, Yongliang Liang, Daniel E.L. Promislow, Lynn M. Wachtman, and Dean P. Jones. 2013. “Characterization of plasma thiol redox potential in a common marmoset model of aging☆.” Redox Biology 1 (1): 387-393. doi:10.1016/j.redox.2013.06.003. http://dx.doi.org/10.1016/j.redox.2013.06.003.Abstract
Due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate model of aging. Blood and extracellular fluid possess two major thiol-dependent redox nodes involving cysteine (Cys), cystine (CySS), glutathione (GSH) and glutathione disulfide (GSSG). Alteration in these plasma redox nodes significantly affects cellular physiology, and oxidation of the plasma Cys/CySS redox potential (EhCySS) is associated with aging and disease risk in humans. The purpose of this study was to determine age-related changes in plasma redox metabolites and corresponding redox potentials (Eh) to further validate the marmoset as a nonhuman primate model of aging. We measured plasma thiol redox states in marmosets and used existing human data with multivariate adaptive regression splines (MARS) to model the relationships between age and redox metabolites. A classification accuracy of 70.2% and an AUC of 0.703 were achieved using the MARS model built from the marmoset redox data to classify the human samples as young or old. These results show that common marmosets provide a useful model for thiol redox biology of aging.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757708/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11877116
Collections
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)