Colonic Patch and colonic SILT development are independent and differentially-regulated events
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Author
Baptista, AP
Olivier, BJ
Goverse, G
Greuter, M
Knippenberg, M
Kusser, K
Domingues, RG.
Veiga-Fernandes, H
Luster, AD
Lugering, A
Randall, TD
Cupedo, T
Mebius, RE
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/mi.2012.90Metadata
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Baptista, A., B. Olivier, G. Goverse, M. Greuter, M. Knippenberg, K. Kusser, R. Domingues, et al. 2012. “Colonic Patch and colonic SILT development are independent and differentially-regulated events.” Mucosal immunology 6 (3): 511-521. doi:10.1038/mi.2012.90. http://dx.doi.org/10.1038/mi.2012.90.Abstract
Intestinal lymphoid tissues have to simultaneously ensure protection against pathogens and tolerance towards commensals. Despite such vital functions, their development in the colon is poorly understood. Here, we show that the two distinct lymphoid tissues of the colon–colonic patches and colonic SILTs–can easily be distinguished based on anatomical location, developmental timeframe and cellular organization. Furthermore, whereas colonic patch development depended on CXCL13-mediated LTi cell clustering followed by LTα-mediated consolidation, early LTi clustering at SILT anlagen did not require CXCL13, CCR6 or CXCR3. Subsequent dendritic cell recruitment to and gp38+VCAM-1+ lymphoid stromal cell differentiation within SILTs required LTα; B cell recruitment and follicular dendritic cell differentiation depended on MyD88-mediated signalling, but not the microflora. In conclusion, our data demonstrate that different mechanisms, mediated mainly by programmed stimuli, induce the formation of distinct colonic lymphoid tissues, therefore suggesting that these tissues may have different functions.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570605/pdf/Terms of Use
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