Genome-wide association study of Tourette Syndrome
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Author
Yu, Dongmei
Mathews, Carol A.
Fagerness, Jesen A
Evans, Patrick
Gamazon, Eric
Edlund, Christopher K.
Service, Susan
Tikhomirov, Anna
Osiecki, Lisa
Pluzhnikov, Anna
Konkashbaev, Anuar
Davis, Lea K
Han, Buhm
Crane, Jacquelyn
Moorjani, Priya
Crenshaw, Andrew T.
Parkin, Melissa A.
Reus, Victor I.
Lowe, Thomas L.
Rangel-Lugo, Martha
Chouinard, Sylvain
Dion, Yves
Girard, Simon
Cath, Danielle C
Smit, Jan H
King, Robert A.
Fernandez, Thomas
Leckman, James F.
Kidd, Kenneth K.
Kidd, Judith R.
Pakstis, Andrew J.
State, Matthew
Herrera, Luis Diego
Romero, Roxana
Fournier, Eduardo
Sandor, Paul
Barr, Cathy L
Phan, Nam
Gross-Tsur, Varda
Benarroch, Fortu
Pollak, Yehuda
Budman, Cathy L.
Bruun, Ruth D.
Erenberg, Gerald
Naarden, Allan L
Lee, Paul C
Weiss, Nicholas
Kremeyer, Barbara
Berrío, Gabriel Bedoya
Campbell, Desmond
Silgado, Julio C. Cardona
Ochoa, William Cornejo
Restrepo, Sandra C. Mesa
Muller, Heike
Duarte, Ana V. Valencia
Lyon, Gholson J
Leppert, Mark
Morgan, Jubel
Weiss, Robert
Grados, Marco A.
Anderson, Kelley
Davarya, Sarah
Singer, Harvey
Walkup, John
Jankovic, Joseph
Tischfield, Jay A.
Heiman, Gary A.
Gilbert, Donald L.
Hoekstra, Pieter J.
Robertson, Mary M.
Kurlan, Roger
Liu, Chunyu
Gibbs, J. Raphael
Singleton, Andrew
Hardy, John
Strengman, Eric
Ophoff, Roel
Wagner, Michael
Moessner, Rainald
Mirel, Daniel B.
Posthuma, Danielle
Sabatti, Chiara
Eskin, Eleazar
Conti, David V.
Knowles, James A.
Ruiz-Linares, Andres
Rouleau, Guy A.
Heutink, Peter
Oostra, Ben A.
McMahon, William
Freimer, Nelson
Cox, Nancy J.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/mp.2012.69Metadata
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Scharf, J. M., D. Yu, C. A. Mathews, B. M. Neale, S. E. Stewart, J. A. Fagerness, P. Evans, et al. 2012. “Genome-wide association study of Tourette Syndrome.” Molecular psychiatry 18 (6): 721-728. doi:10.1038/mp.2012.69. http://dx.doi.org/10.1038/mp.2012.69.Abstract
Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel, and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (p<5 × 10−8); the top signal was found in rs7868992 on chromosome 9q32 within COL27A1 (p=1.85 × 10−6). A secondary analysis including an additional 211 cases and 285 controls from two closely-related Latin-American population isolates from the Central Valley of Costa Rica and Antioquia, Colombia also identified rs7868992 as the top signal (p=3.6 × 10−7 for the combined sample of 1496 cases and 5249 controls following imputation with 1000 Genomes data). This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605224/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879249
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