Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes
View/ Open
Author
Wang, Fei
Guo, Ye
Chen, Qian
Yang, Zhuo
Ning, Ning
Zhang, Yujuan
Xu, Yonggang
Xu, Xiaodong
Tong, Chunrong
Cui, Wei
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1186/1756-8722-6-73Metadata
Show full item recordCitation
Wang, F., Y. Guo, Q. Chen, Z. Yang, N. Ning, Y. Zhang, Y. Xu, et al. 2013. “Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes.” Journal of Hematology & Oncology 6 (1): 73. doi:10.1186/1756-8722-6-73. http://dx.doi.org/10.1186/1756-8722-6-73.Abstract
Background: Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases with variable clinical course. Predicting disease progression is difficult due to lack of specific molecular marker(s). SALL4 plays important roles in normal hematopoiesis and leukemogenesis. SALL4 transgenic mice develop MDS prior to acute myeloid leukemia (AML) transformation. However, the role of SALL4 in human MDS has not been extensively investigated. In this study, we evaluate the diagnostic/prognostic value of SALL4 in MDS by examining its expression levels in a cohort of MDS patients. Methods: Fifty-five newly diagnosed MDS, twenty MDS-AML, and sixteen post-treatment MDS patients were selected for our study along with ten healthy donors. Results: We demonstrated that SALL4 was over-expressed in MDS patients and proportionally increased in MDS patients with high grade/IPSS scores. This expression pattern was similar to that of Bmi-1, an important marker in predicting MDS/AML progression. In addition, the level of SALL4 was positively correlated with increased blast counts, high-risk keryotypes and increased significantly in MDS-AML transformation. Furthermore, higher level of SALL4 expression was associated with worse survival rates and SALL4 level decreased following effective therapy. Conclusions: To the best of our knowledge, this is the largest series and the first to report the expression pattern of SALL4 in detail in various subtypes of MDS in comparison to that of Bmi-1. We conclude that SALL4 is a potential molecular marker in predicting the prognosis of MDS.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856454/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879339
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)