Development of an open-source, flexible framework for complex inter-institutional disparate data sharing and collaboration
View/ Open
Author
Kirby, Chaim
Ambros, Peter F.
Billiter, David
Mendonca, Eneida
Monclair, Tom
Pearson, Andrew D. J.
Cohn, Susan L.
Volchenboum, Samuel L.
Metadata
Show full item recordCitation
Kirby, Chaim, Peter F. Ambros, David Billiter, Wendy B. London, Eneida Mendonca, Tom Monclair, Andrew D. J. Pearson, Susan L. Cohn, and Samuel L. Volchenboum. 2013. “Development of an open-source, flexible framework for complex inter-institutional disparate data sharing and collaboration.” AMIA Summits on Translational Science Proceedings 2013 (1): 103.Abstract
Clinical information, “-omic” datasets, and tissue samples are difficult to harmonize and manage for data mining. We have developed a platform for storing clinical research data while providing access to associated data from other information stores. Data on 34 metrics from 11,000 neuroblastoma patients were instantiated into a database. The Django web framework was used to create a model for rapid development of tools and views with a front-end interface for generating complex queries. Working with Nationwide Children’s Hospital, we can now consume their tissue inventory data through an API. The end-user sees the number of patients who both match their search and have tissue available. Since initial implementation, the current tasks revolve around developing a governance structure and the necessary data use agreements. Efforts now are to (1) update the data with 5000 more patients, and (2) link to genomic data stores, facilitating disparate data acquisition for research studies.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814475/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879409
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)