Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men – the role of gut microbiota composition: study protocol for the AELC randomized controlled trial
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Author
Liu, Wu Yi
Lu, Da Jiang
Du, Xia Ming
Sun, Jian Qin
Ge, Jun
Wang, Ren Wei
Wang, Ru
Zou, Jun
Xu, Chang
Ren, Jie
Wen, Xin Fei
Liu, Yang
Cheng, Shu Mei
Tan, Xiao
Pekkala, Satu
Munukka, Eveliina
Wiklund, Petri
Chen, Yan Qiu
Gu, Qing
Xia, Zheng Chang
Liu, Jun Jun
Liu, Wen Bin
Chen, Xue Bo
Zhang, Yi Min
Li, Rui
Yao, Jia Xin
Chen, Pei Jie
Cheng, Sulin
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1186/1471-2458-14-48Metadata
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Liu, W. Y., D. J. Lu, X. M. Du, J. Q. Sun, J. Ge, R. W. Wang, R. Wang, et al. 2014. “Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men – the role of gut microbiota composition: study protocol for the AELC randomized controlled trial.” BMC Public Health 14 (1): 48. doi:10.1186/1471-2458-14-48. http://dx.doi.org/10.1186/1471-2458-14-48.Abstract
Background: Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualified subjects are randomized into 4 groups with 50 subjects in each group: 1 = AEx, 2 = LCh, 3 = AEx + LCh, and 4 = control. In addition, two age-matched reference groups (5 = pre-diabetes without NAFLD (n = 50) and 6 = Healthy without pre-diabetes or NAFLD (n = 50)) are included. The exercise program consists of progressive and variable aerobic exercise (intensity of 60 to 75% of initial fitness level, 3–5 times/week and 30–60 min/time). The diet program includes dietary consultation plus supplementation with a special lunch meal (40% of total energy intake/day) which aims to reduce the amount of carbohydrate consumption (30%). The control and reference groups are advised to maintain their habitual habits during the intervention. The primary outcome measures are HFC, serum metabolomics and gut microbiota composition. The secondary outcome measures include body composition and cytokines. In addition, socio-psychological aspects, social support, physical activity and diet will be performed by means of questionnaire and interview. Discussion Specific individualized exercise and diet intervention in this study offers a more efficient approach for liver fat reduction and diabetes prevention via modification of gut microbiota composition. Besides, the study explores the importance of incorporating fitness assessment and exercise in the management of patients with pre-diabetes and fatty liver disorders. If our program is shown to be effective, it will open new strategies to combat these chronic diseases. Trial registration Current Controlled Trials: ISRCTN42622771.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897962/pdf/Terms of Use
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