Bacteria activate sensory neurons that modulate pain and inflammation
View/ Open
Author
Von Hehn, Christian A.
Zhao, Fan
Tran, Johnathan
Strominger, Amanda
Muralidharan, Sriya
Horswill, Alexander R.
Wardenburg, Juliane Bubeck
Hwang, Sun Wook
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/nature12479Metadata
Show full item recordCitation
Chiu, I. M., B. A. Heesters, N. Ghasemlou, C. A. Von Hehn, F. Zhao, J. Tran, B. Wainger, et al. 2013. “Bacteria activate sensory neurons that modulate pain and inflammation.” Nature 501 (7465): 52-57. doi:10.1038/nature12479. http://dx.doi.org/10.1038/nature12479.Abstract
Summary Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviors. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed secondary to immune activation. Here we demonstrate that bacteria directly activate nociceptors, and that the immune response mediated through TLR2, MyD88, T cells, B cells, and neutrophils/monocytes is not necessary for Staphylococcus aureus induced pain in mice. Mechanical and thermal hyperalgesia parallels live bacterial load rather than tissue swelling or immune activation. Bacteria induce calcium flux and action potentials in nociceptor neurons, in part via bacterial N-formylated peptides and the pore-forming toxin alpha-hemolysin through distinct mechanisms. Specific ablation of Nav1.8-lineage neurons, which include nociceptors, abrogated pain during bacterial infection, but concurrently increased local immune infiltration and lymphadenopathy of the draining lymph node. Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773968/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12064352
Collections
- FAS Scholarly Articles [18256]
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)