Animals in a Bacterial World, A New Imperative for the Life Sciences
View/ Open
Author
McFall-Ngai, M.
Hadfield, M. G.
Bosch, T. C. G.
Carey, H. V.
Domazet-Loso, T.
Douglas, A. E.
Dubilier, N.
Eberl, G.
Fukami, T.
Gilbert, S. F.
Hentschel, U.
King, N.
Kjelleberg, S.
Kremer, N.
Mazmanian, S. K.
Metcalf, J. L.
Nealson, K.
Rawls, J. F.
Reid, A.
Ruby, E. G.
Rumpho, M.
Tautz, D.
Wernegreen, J. J.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1073/pnas.1218525110Metadata
Show full item recordCitation
McFall-Ngai, M., M. G. Hadfield, T. C. G. Bosch, H. V. Carey, T. Domazet-Loso, A. E. Douglas, N. Dubilier, et al. 2013. Animals in a Bacterial World, a New Imperative for the Life Sciences. Proceedings of the National Academy of Sciences 110, no. 9: 3229–3236.Abstract
In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal–bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal–bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587249/http://www.oeb.harvard.edu/faculty/pierce/publications/pdfs/2013_McFall-Ngai_et_al_Animals_in_a_bacterial_world.pdf
http://authors.library.caltech.edu/37809/1/PNAS-2013-McFall-Ngai-3229-36.pdf
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12336337
Collections
- FAS Scholarly Articles [18292]
Contact administrator regarding this item (to report mistakes or request changes)