The complete genome sequence of a Neandertal from the Altai Mountains
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Author
Prüfer, Kay
Racimo, Fernando
Patterson, Nick
Jay, Flora
Sankararaman, Sriram
Sawyer, Susanna
Heinze, Anja
Renaud, Gabriel
Sudmant, Peter H.
de Filippo, Cesare
Li, Heng
Dannemann, Michael
Fu, Qiaomei
Kircher, Martin
Kuhlwilm, Martin
Lachmann, Michael
Meyer, Matthias
Ongyerth, Matthias
Siebauer, Michael
Theunert, Christoph
Moorjani, Priya
Mullikin, James C.
Vohr, Samuel H.
Green, Richard E.
Hellmann, Ines
Johnson, Philip L. F.
Blanche, Hélène
Cann, Howard
Kitzman, Jacob O.
Shendure, Jay
Eichler, Evan E.
Lein, Ed S.
Bakken, Trygve E.
Golovanova, Liubov V.
Doronichev, Vladimir B.
Shunkov, Michael V.
Derevianko, Anatoli P.
Viola, Bence
Slatkin, Montgomery
Kelso, Janet
Pääbo, Svante
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nature12886Metadata
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Prüfer, K., F. Racimo, N. Patterson, F. Jay, S. Sankararaman, S. Sawyer, A. Heinze, et al. 2014. “The complete genome sequence of a Neandertal from the Altai Mountains.” Nature 505 (7481): 43-49. doi:10.1038/nature12886. http://dx.doi.org/10.1038/nature12886.Abstract
We present a high-quality genome sequence of a Neandertal woman from Siberia. We show that her parents were related at the level of half siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neandertal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neandertals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high quality Neandertal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neandertals and Denisovans.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
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